Direction of estradiol metabolism as a control of its hormonal action--uterotrophic activity of estradiol metabolites

Endocrinology
C P Martucci, J Fishman

Abstract

The uterotrophic activities of the catechol metabolites of estradiol 2-hydroxyestrone, 2-methoxyestrone and 2-hydroxyestradiol were measured under conditions of continuous administration of sc implanted paraffin pellets. The activity of these estrogens was compared to that of estradiol-17beta and its other principal metabolites estrone, estriol and 15alpha-hydroxyestriol (estetrol). The major catechol estrogens, 2-hydroxyestrone and 2-methoxyestrone, and the pregnancy metabolite, 15alpha-hydroxyestriol, exhibited no uterotrophic activity. The minor catecholestrogen, 2-hydroxyestradiol, showed some activity whose character was different from that exhibited by implants of estradiol, estrone and estriol all of which were equipotent uterotrophic agents. Implants of 2-hydroxyestrone in the presence of estradiol or estriol pellets did not diminish the response to the latter indicating that the 2-hydroxyestrone is not antiestrogenic under these conditions. It is concluded that the direction of estradiol metabolism can have a profound influence on the expression of peripheral hormonal activity with hydroxylation at C-2 terminating and hydroxylation at C-16 extending it.

Citations

Nov 1, 1979·Arthritis and Rheumatism·R G LahitaJ Fishman
Apr 5, 2007·Calcified Tissue International·Nicola NapoliReina C Armamento-Villareal
Jan 1, 1980·Journal of Steroid Biochemistry·H A ErikssonJ H Clark
Dec 1, 1981·Journal of Steroid Biochemistry·J H Clark, B M Markaverich
Dec 1, 1981·Journal of Steroid Biochemistry·N J MacLuskyS Franks
Aug 1, 1982·Journal of Steroid Biochemistry·M NumazawaT Nambara
Apr 1, 1984·Journal of Steroid Biochemistry·J H Clark, B M Markaverich
Apr 1, 1984·Journal of Steroid Biochemistry·J FishmanH L Bradlow
Aug 1, 1988·Journal of Steroid Biochemistry·E R BarneaF Naftolin
Sep 1, 1992·Steroids·L A CastagnettaG P Cartoni
Jan 1, 1983·Pharmacology & Therapeutics·J H Clark, B M Markaverich
Feb 1, 1993·Pharmacology & Therapeutics·C P Martucci, J Fishman
Jan 1, 1986·Progress in Lipid Research·R A Karmali
Jul 1, 1988·European Journal of Cancer & Clinical Oncology·Y J Abul-HajjM A Blankenstein
Jan 1, 1989·Psychoneuroendocrinology·D Saphier
Nov 1, 1995·Critical Reviews in Oncology/hematology·E Lønning, E A Lien
Jun 6, 2000·Reproductive Toxicology·G D CharlesE W Carney
May 31, 2001·Clinical Endocrinology·M J Reed, Atul Purohit
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J FishmanA Kappas
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J SchneiderJ Fishman
Dec 1, 1988·The Journal of Cell Biology·D D CarsonS R Glasser
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R LeelawattanaR Civitelli
Oct 29, 2013·Endocrine-related Cancer·Douglas A Gibson, Philippa T K Saunders
Oct 1, 1996·Archiv der Pharmazie·K A IsmailS H el-Rewini
Dec 19, 1979·Biochimica Et Biophysica Acta·T L Dao
May 1, 1987·American Journal of Obstetrics and Gynecology·R W Lievertz
May 9, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Christian F HolinkaHerjan J T Coelingh Bennink
Mar 3, 2004·International Journal of Cancer. Journal International Du Cancer·Simon P NewmanMichael J Reed
Mar 3, 2009·Annals of the New York Academy of Sciences·D W Sepkovic, H L Bradlow
Jul 1, 1987·Metabolism: Clinical and Experimental·C LongcopeL E Braverman
Jul 1, 1982·Arthritis and Rheumatism·R G LahitaH G Kunkel
Jan 30, 2015·Critical Reviews in Food Science and Nutrition·Venkidasamy BaskarShivraj Hariram Nile
Apr 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A M FranchiM A Gimeno
Mar 10, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·H J YooS P Schantz
Jun 1, 2017·Breast Cancer Research and Treatment·Cynthia A ThomsonPatricia A Thompson
Dec 1, 1999·Nutrition and Cancer·M C MartiniJ L Slavin
Sep 1, 1988·Asia-Oceania Journal of Obstetrics and Gynaecology·S KonoH Sunagawa
Jun 1, 1987·Journal of Endocrinological Investigation·E R Barnea, F Naftolin
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·G KranzfelderA E Bogden
Jan 1, 1983·American Journal of Primatology·P I MuseyJ R Preedy
Oct 2, 1982·The Medical Journal of Australia·B G WrenD A Routledge
Apr 1, 1979·The American Journal of Physiology·D C CollinsJ R Preedy

Related Concepts

Estradiol, (16 alpha,17 beta)-Isomer
Ovestin
Hydroxyestrones
Structure-Activity Relationship
Uterus

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