Directional and temporal variation of the mechanical properties of robocast scaffold during resorption

Journal of Materials Science. Materials in Medicine
J WaygoodT Fiedler

Abstract

This paper addresses the mechanical behavior of robocast PCL-Bioglass(®) scaffolds. These structures can be used as 3rd generation implants in tissue engineering to support the regrowth of damaged tissue, in particular bone. After successful tissue regeneration the scaffolds slowly dissolve leaving no foreign material permanently inside the body. However, to avoid mechanical separation from surrounding tissue they must exhibit similar mechanical properties. The present study introduces a detailed numerical study focusing on the determination of effective mechanical material properties, their anisotropy, and mechanical degradation due to scaffold resorption. In order to accurately capture the complex scaffold geometry, micro-computed tomography scans of actual samples are conducted. The resulting three-dimensional data are directly converted into finite element calculation models. Numerical compressive tests of these unmodified models are repeated for three perpendicular directions to investigate mechanical anisotropy, after which the effect of scaffold degradation due to exposure to body fluid is simulated. To this end, two different resorption models, namely surface erosion and bulk degradation, are applied to the micro-comput...Continue Reading

References

May 23, 2001·Advanced Drug Delivery Reviews·J Siepmann, A Göpferich
Aug 17, 2005·Biomaterials·Julian R JonesLarry L Hench
Oct 4, 2005·Biomaterials·Hongfan SunPengyan Wang
Aug 11, 2007·Journal of Biomedical Materials Research. Part a·Pedro MirandaFernando Guiberteau
Nov 22, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mika PulkkinenKristiina Järvinen
Aug 7, 2010·Acta Biomaterialia·Johan Van der StokPeter Patka
Nov 13, 2010·Journal of Materials Science. Materials in Medicine·J M Meseguer-DueñasA Vidaurre
Nov 28, 2012·Advanced Healthcare Materials·Umut Atakan GurkanUtkan Demirci
Oct 12, 2013·ACS Applied Materials & Interfaces·Chien-Shen YangTzu-Wei Wang
May 27, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenZhiyuan Zhong
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·T FiedlerJ M F Ferreira

❮ Previous
Next ❯

Citations

Mar 16, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Zhitao LiuHuanxin Lai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.