Directional asymmetry of neurons in cortical areas MT and MST projecting to the NOT-DTN in macaques

Journal of Neurophysiology
K P HoffmannClaudia Distler

Abstract

The cortical projection to the subcortical pathway underlying the optokinetic reflex was studied using antidromic electrical stimulation in the midbrain structures nucleus of the optic tract and dorsal terminal nucleus of the accessory optic system (NOT-DTN) while simultaneously recording from cortical neurons in the superior temporal sulcus (STS) of macaque monkeys. Projection neurons were found in all subregions of the middle temporal area (MT) as well as in the medial superior temporal area (MST). Antidromic latencies ranged from 0.9 to 6 ms with a median of 1.8 ms. There was a strong bias in the population of cortical neurons projecting to the NOT-DTN for ipsiversive stimulus movement (towards the recording side), whereas in the population of cortical neurons not projecting to the NOT-DTN a more or less equal distribution of stimulus directions was evident. Our data indicate that there is no special area in the posterior STS coding for ipsiversive horizontal stimulus movement. Instead, a specific selection of cortical neurons from areas MT and MST forms the projection to the NOT-DTN and as a subpopulation has the same directional bias as their subcortical target neurons. These findings are discussed in relation to the funct...Continue Reading

References

Jan 1, 1979·Neurological Research·F Gallyas
Jan 1, 1991·Experimental Brain Research·R G Erickson, P Thier
Jul 1, 1989·Journal of Neurophysiology·H Komatsu, R H Wurtz
Sep 1, 1988·Journal of Neurophysiology·M R Dürsteler, R H Wurtz
Feb 1, 1988·Annals of Neurology·R J Tusa, L G Ungerleider
Dec 1, 1987·Journal of Neurophysiology·M A Segraves, M E Goldberg
Oct 1, 1987·Journal of Neurophysiology·D S ZeeG Gücer
Jan 10, 1984·The Journal of Comparative Neurology·J Szabo, W M Cowan
Jan 1, 1983·Experimental Brain Research·J C Lynch, J W McLaren
May 1, 1983·Journal of Neuroscience Methods·D T Hess, B H Merker
May 15, 1980·The Journal of Comparative Neurology·D C Van Essen, J H Maunsell
Apr 1, 1995·Annals of Neurology·M J Morrow, J A Sharpe
Nov 1, 1994·The Journal of Comparative Neurology·M J MustariF R Robinson
Oct 21, 1993·Behavioural Brain Research·U J IlgK P Hoffmann
Aug 1, 1993·The Journal of Comparative Neurology·C DistlerL G Ungerleider
Aug 1, 1993·Journal of Neurophysiology·U J Ilg, K P Hoffmann
Jan 1, 1993·Journal of Neurophysiology·L LagaeG A Orban
Mar 1, 1996·Current Biology : CB·O Braddick
Sep 9, 1996·The Journal of Comparative Neurology·J A Büttner-EnneverH Reisine
Oct 1, 1996·Brain : a Journal of Neurology·J J BartonJ E Raymond
Dec 1, 1996·Brain : a Journal of Neurology·W HeideD Kömpf
Dec 24, 1998·Journal of Neurophysiology·M A Sommer, R H Wurtz
May 10, 2000·Experimental Brain Research·S B YakushinB Cohen

❮ Previous
Next ❯

Citations

Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·A ThieleK-P Hoffmann
May 6, 2005·Journal of Neurophysiology·Anne K Churchland, Stephen G Lisberger
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Trinity B Crapse, Marc A Sommer
Apr 23, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·H J Simonsz, G H Kolling
Dec 10, 2003·Annals of the New York Academy of Sciences·C Distler, K-P Hoffmann
Aug 4, 2009·Annals of the New York Academy of Sciences·Olivia Andrea Masseck, Klaus-Peter Hoffmann
Nov 21, 2008·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Agnes M F Wong
Apr 9, 2005·The European Journal of Neuroscience·Gleb BarmashenkoKlaus-Peter Hoffmann
Jan 18, 2018·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Cristian Gutierrez-IbanezDouglas R Wylie
Apr 5, 2008·Neuroreport·Dmitry DiykovKlaus-Peter Hoffmann
Sep 27, 2008·Experimental Brain Research·Takeharu Seno, Takao Sato
May 11, 2004·Nature Neuroscience·Juergen Haag, Alexander Borst
Oct 27, 2006·Journal of Neurophysiology·Uwe J Ilg, Stefan Schumann
Jul 10, 2019·Journal of Vision·Alexander GoettkerKarl R Gegenfurtner
Oct 15, 2014·The American Orthoptic Journal·Eleni Papanagnu, Michael C Brodsky
Nov 24, 2015·Annual Review of Vision Science·Stephen G Lisberger
Dec 16, 2011·Journal of Neurophysiology·X ChenA Thiele
Mar 13, 2013·Strabismus·Christopher M KnappIrene Gottlob
Feb 11, 2003·Progress in Neurobiology·C W G Clifford, M R Ibbotson
Mar 23, 2005·Vision Research·Rain G Bosworth, Eileen E Birch
Nov 14, 2008·Brain and Cognition·James A Sharpe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.