Directional control of a processive molecular hopper

Science
Yujia QingHagan Bayley

Abstract

Intrigued by the potential of nanoscale machines, scientists have long attempted to control molecular motion. We monitored the individual 0.7-nanometer steps of a single molecular hopper as it moved in an electric field along a track in a nanopore controlled by a chemical ratchet. The hopper demonstrated characteristics desired in a moving molecule: defined start and end points, processivity, no chemical fuel requirement, directional motion, and external control. The hopper was readily functionalized to carry cargos. For example, a DNA molecule could be ratcheted along the track in either direction, a prerequisite for nanopore sequencing.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D M Rothwarf, H A Scheraga
Dec 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M Montal, P Mueller
Sep 18, 1999·Nature·N KoumuraB L Feringa
Aug 22, 2001·Protein Science : a Publication of the Protein Society·W A Breyer, B W Matthews
May 2, 2002·Journal of the American Chemical Society·Janani VenkatramanPadmanabhan Balaram
Jun 19, 2002·Protein Science : a Publication of the Protein Society·George MilesStephen Cheley
Dec 24, 2002·Biophysical Journal·Stefan Howorka, Hagan Bayley
Dec 26, 2003·Chemistry : a European Journal·Pedro Alexandrino Fernandes, Maria João Ramos
Jul 9, 2004·Biophysical Journal·Jonathan NakaneAndre Marziali
Sep 2, 2004·Journal of the American Chemical Society·Jong-Shik Shin, Niles A Pierce
Feb 1, 2007·Journal of the American Chemical Society·Vijay M KrishnamurthyGeorge M Whitesides
Nov 2, 2007·Nature·Arun P WiitaJulio M Fernandez
Dec 7, 2007·The Journal of Organic Chemistry·Robert D BachColin Thorpe
Dec 17, 2008·Science·Alexander B C DeutmanAlan E Rowan
Jan 31, 2009·Current Opinion in Cell Biology·Arne Gennerich, Ronald D Vale
Aug 8, 2009·The EMBO Journal·Borja IbarraCarlos Bustamante
Sep 12, 2009·Angewandte Chemie·Christopher A Hunter, Harry L Anderson
May 14, 2010·Nature·Hongzhou GuNadrian C Seeman
Jun 24, 2010·Angewandte Chemie·Anne F HammersteinHagan Bayley
Oct 19, 2010·Angewandte Chemie·Michael J BarrellDavid A Leigh
Dec 3, 2010·Nature Chemistry·Max von DeliusDavid A Leigh
Feb 8, 2011·Nature Nanotechnology·Shelley F J WickhamAndrew J Turberfield
Feb 3, 2012·Angewandte Chemie·Mingxu YouWeihong Tan
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Wilhelm J WalterWalter Steffen
Apr 11, 2012·Angewandte Chemie·Araceli G CampañaKathleen M Mullen
May 16, 2013·Journal of the American Chemical Society·Araceli G CampañaUrszula Lewandowska
Dec 10, 2013·Nature Nanotechnology·Tae-Gon ChaJong Hyun Choi
Mar 22, 2014·Nature Reviews. Molecular Cell Biology·Robert A Cross, Andrew McAinsh
Dec 6, 2014·Clinical Chemistry·Hagan Bayley
Dec 9, 2014·Nature Nanotechnology·Gökçe Su PulcuHagan Bayley
May 20, 2015·Nature Nanotechnology·Chuyang ChengJ Fraser Stoddart
Sep 9, 2015·Chemical Reviews·Sundus Erbas-CakmakAlina L Nussbaumer
Dec 1, 2015·Nature Nanotechnology·Kevin YehlKhalid Salaita
Jun 10, 2016·Nature·Miriam R WilsonDavid A Leigh
Sep 22, 2017·Nature·Salma KassemSimone Pisano
Oct 21, 2017·Science·Sundus Erbas-CakmakMiriam R Wilson

❮ Previous
Next ❯

Citations

Aug 10, 2019·Chemical Communications : Chem Comm·David J Nelson, Joanna Wencel-Delord
Aug 24, 2019·Angewandte Chemie·Eszter Baráth, Esteban Mejía
Nov 20, 2019·Nature Nanotechnology·Yujia QingHagan Bayley
Jun 5, 2020·Science Advances·Alice L ThorneyworkUlrich F Keyser
Nov 18, 2020·The Journal of Membrane Biology·Kozhinjampara R Mahendran
May 15, 2021·Biochimica Et Biophysica Acta. Biomembranes·Joseph W F RobertsonJoseph E Reiner
Mar 14, 2019·ACS Nano·Marius M HauglandScott L Cockroft
Dec 22, 2020·Nano Letters·Mariam BayoumiGiovanni Maglia
May 12, 2020·The Journal of Physical Chemistry Letters·Jige Chen
Dec 19, 2018·Bioconjugate Chemistry·Tulsi Ram Damase, Peter B Allen
Mar 18, 2020·Analytical Chemistry·Si-Min LuYi-Tao Long
Apr 2, 2019·Journal of the American Chemical Society·Gökçe Su PulcuHagan Bayley
Sep 2, 2021·JACS Au·Quentin LaurentStefan Matile
Oct 21, 2021·Journal of the American Chemical Society·Yujia Qing, Hagan Bayley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Protein Science : a Publication of the Protein Society
Carlos Bustamante
Biophysics Reviews
Robert Cross, Claudia Veigel
© 2022 Meta ULC. All rights reserved