Directional coupling of oligodendrocyte connexin-47 and astrocyte connexin-43 gap junctions

Glia
Ilaria FascianiLuis C Barrio

Abstract

Intercellular communication via gap junction channels between oligodendrocytes and between astrocytes as well as between these cell types is essential to maintain the integrity of myelin in the central nervous system. Oligodendrocyte gap junction connexin-47 (Cx47) is a key element in this crosstalk and indeed, mutations in human Cx47 cause severe myelin disorders. However, the permeation properties of channels of Cx47 alone and in heterotypic combination with astrocyte Cx43 remain unclear. We show here that Cx47 contains three extra residues at 5' amino-terminus that play a critical role in the channel pore structure and account for relative low ionic conductivity, cationic permselectivity and voltage-gating properties of oligodendrocyte-oligodendrocyte Cx47 channels. Regarding oligodendrocyte-astrocyte coupling, heterotypic channels formed by Cx47 with Cx43 exhibit ionic and chemical rectification, which creates a directional diffusion barrier for the movement of ions and larger negatively charged molecules from cells expressing Cx47 to those with Cx43. The restrictive permeability of Cx47 channels and the diffusion barrier of Cx47-Cx43 channels was abolished by a mutation associated with leukodystrophy, the Cx47P90S, suggest...Continue Reading

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Citations

Feb 15, 2019·Frontiers in Cellular Neuroscience·Sebastián VejarJuan A Orellana
Dec 14, 2019·Cellular and Molecular Life Sciences : CMLS·Xin LiLize Xiong
Dec 1, 2019·International Journal of Molecular Sciences·Laura Medina-CejaAlberto Morales-Villagrán
Aug 28, 2020·Frontiers in Neuroscience·Michal IzraelMichel Revel
Apr 25, 2020·Physiological Reviews·Christian GiaumeLuc Leybaert
Mar 26, 2021·Frontiers in Cell and Developmental Biology·Greg J DuncanBen Emery
Jun 13, 2021·Progress in Neurobiology·Shuai ZhangXiaofeng Jia

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