Directional Local Field Potentials in the Subthalamic Nucleus During Deep Brain Implantation of Parkinson's Disease Patients

Frontiers in Human Neuroscience
T A Khoa NguyenClaudio Pollo

Abstract

Segmented deep brain stimulation leads feature directional electrodes that allow for a finer spatial control of electrical stimulation compared to traditional ring-shaped electrodes. These segmented leads have demonstrated enlarged therapeutic windows and have thus the potential to improve the treatment of Parkinson's disease patients. Moreover, they provide a unique opportunity to record directional local field potentials. Here, we investigated whether directional local field potentials can help identify the best stimulation direction to assist device programming. Four Parkinson's disease patients underwent routine implantation of the subthalamic nucleus. Firstly, local field potentials were recorded in three directions for two conditions: In one condition, the patient was at rest; in the other condition, the patient's arm was moved. Secondly, current thresholds for therapeutic and side effects were identified intraoperatively for directional stimulation. Therapeutic windows were calculated from these two thresholds. Thirdly, the spectral power of the total beta band (13-35 Hz) and its sub-bands low, high, and peak beta were analyzed post hoc. Fourthly, the spectral power was used by different algorithms to predict the ranking...Continue Reading

References

May 23, 2002·Brain : a Journal of Neurology·Ron LevyJonathan O Dostrovsky
Feb 13, 2004·Brain : a Journal of Neurology·Andrea A KühnPeter Brown
Sep 1, 2006·The New England Journal of Medicine·Günther DeuschlUNKNOWN German Parkinson Study Group, Neurostimulation Section
May 29, 2007·Trends in Neurosciences·Constance HammondPeter Brown
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea A KühnPeter Brown
Jan 8, 2009·JAMA : the Journal of the American Medical Association·Frances M WeaverUNKNOWN CSP 468 Study Group
May 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Jens VolkmannYves Agid
Nov 23, 2013·Parkinsonism & Related Disorders·Ido StraussAndres M Lozano
May 23, 2014·Brain : a Journal of Neurology·Claudio PolloMichael Schüpbach
Aug 26, 2014·Neurology·M Fiorella ContarinoP R Schuurman
Oct 2, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Simon LittlePeter Brown
Jun 1, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Frank SteigerwaldJens Volkmann
Mar 25, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Carla Fernández-GarcíaFernando Alonso-Frech
Aug 27, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Till A DembekLars Timmermann
Oct 21, 2017·Brain : a Journal of Neurology·Gerd TinkhauserPeter Brown
Nov 19, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Gerd TinkhauserMichael Schuepbach
Mar 24, 2018·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Xinyi GengShouyan Wang
Apr 14, 2018·Journal of Neural Engineering·Simeng ZhangMatthew D Johnson
Apr 18, 2018·Brain Stimulation·Timo R Ten BrinkeRob M A de Bie
Apr 19, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Mark D HumphriesJakob Kisbye Dreyer
Jun 18, 2018·Neurobiology of Disease·Gerd TinkhauserPeter Brown
Jul 19, 2018·Journal of Neurophysiology·Nicholas MalingCameron C McIntyre
Aug 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ilknur TelkesNuri F Ince
Jan 9, 2019·Frontiers in Computational Neuroscience·Eli J Müller, Peter A Robinson
Mar 25, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gerd TinkhauserPeter Brown

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01764815

Software Mentioned

Matlab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.