Directional migration of adult hematopoeitic progenitors to C6 glioma in vitro

Oncology Letters
Igor Stepanovich BryukhovetskiyAndrei Stepanovich Bryukhovetskiy

Abstract

Multiform glioblastoma is the most common primary, highly invasive, malignant tumor of the central nervous system, with an extremely poor prognosis. The median survival of patients following surgical resection, radiation therapy and chemotherapy does not exceed 12-15 months and thus, novel approaches for the treatment of the disease are required. The phenomenon of the directed migration of stem cells in tumor tissue presents a novel approach for the development of technologies that facilitate the targeted delivery of drugs and other therapeutic agents to the tumor foci. Hematopoietic cluster of differentiation (CD)34(+)/CD133(+) stem cells possess significant reparative potential and are inert with respect to normal neural tissue. The aim of the present study was to investigate the substantiation ability of adult hematopoietic progenitors to the directed migration of glioma cells. A C6 glioma cell line, a culture of hematopoietic CD34(+)/CD133(+) stem cells and primary cultures of rat astrocytes and fibroblasts were used. The cells were co-cultured for five days. The results revealed the formation of cell shaft hematopoietic stem cells on the perimeter of the culture inserts containing the glioma culture. However, this was not ...Continue Reading

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Citations

May 12, 2018·International Journal of Molecular Medicine·Igor BryukhovetskiyYuri Khotimchenko
Oct 26, 2016·Molecular Medicine Reports·Igor S BryukhovetskiyYuri S Khotimchenko
Nov 1, 2017·Human Vaccines & Immunotherapeutics·Ziren KongWenbin Ma
Nov 10, 2015·Oncology Reports·Igor BryukhovetskiyPolina Mischenko
Apr 3, 2020·Cellular and Molecular Neurobiology·Marcelo Augusto Germani MarinhoAna Paula Horn
Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Henry Ruiz-GarciaDaniel M Trifiletti

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enzymatic dissociation
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