Directional Posterior Corneal Profile Changes in Fuchs' Endothelial Corneal Dystrophy

Investigative Ophthalmology & Visual Science
Katrin WackerSanjay V Patel

Abstract

To determine directional changes in peripheral corneal thickness and corneal astigmatism over a range of severity of Fuchs' endothelial corneal dystrophy (FECD). Eyes with FECD were categorized as mild, moderate, or advanced according to the area and confluence of guttae and the presence of clinical edema. Normal corneas were devoid of guttae. Peripheral thickness centered on the corneal apex, and radii of posterior curvature were measured with Scheimpflug imaging. Variables were compared between groups by using generalized estimating equation models. Scheimpflug images were acquired in 101 normal corneas and 112 corneas with FECD. Normal corneas were 8.6 ± 4.8 μm thicker vertically than horizontally (P = 0.001); the steep posterior meridian was vertical in 91% of corneas. The difference between vertical and horizontal thicknesses decreased to 4.7 ± 7.3 μm in advanced FECD (P = 0.008); 46% had a steep vertical posterior meridian (P = 0.001). Vertical radius of curvature was flatter than normal in moderate (by 0.2 mm, P = 0.011) and advanced (by 0.4 mm, P < 0.001) FECD. Mean posterior corneal power was less negative in moderate (by 0.2 diopters [D], P = 0.009) and advanced (by 0.4 D, P < 0.001) FECD compared to normal. Posterior...Continue Reading

Citations

Jul 12, 2018·European Journal of Ophthalmology·Victor A AugustinTheofilos Tourtas
Jul 3, 2019·Journal of Cataract and Refractive Surgery·Mehdi ShajariIngo Schmack
Sep 24, 2016·Cornea·Korine van DijkGerrit R J Melles
Nov 8, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K WackerP Maier
Jul 26, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Viviane GrewingKatrin Wacker
Sep 11, 2020·The British Journal of Ophthalmology·Victor A AugustinTheofilos Tourtas
Jan 9, 2021·The British Journal of Ophthalmology·Jack A CampbellDivya Srikumaran
Jan 8, 2021·Biomedical Optics Express·Elias PavlatosYan Li
Nov 14, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Raphael DienerMaged Alnawaiseh
Aug 5, 2021·Clinical Ophthalmology·Sudi Patel, Larysa Tutchenko

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