PMID: 18193497Jan 15, 2008Paper

Directly administered antiretroviral therapy for HIV-infected drug users does not have an impact on antiretroviral resistance: results from a randomized controlled trial

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Duncan Smith-Rohrberg MaruFrederick L Altice

Abstract

Directly administered antiretroviral therapy (DAART) is an effective intervention that improves clinical outcomes among HIV-infected drug users. Its effects on antiretroviral drug resistance, however, are unknown. We conducted a community-based, prospective, randomized controlled trial of DAART compared with self-administered therapy (SAT). We performed a modified intention-to-treat analysis among 115 subjects who provided serum samples for HIV genotypic resistance testing at baseline and at follow-up. The main outcomes measures included total genotypic sensitivity score, future drug options, number of new drug resistance mutations (DRMs), and number of new major International AIDS Society (IAS) mutations. The adjusted probability of developing at least 1 new DRM did not differ between the 2 arms (SAT: 0.41 per person-year [PPY], DAART: 0.49 PPY; adjusted relative risk [RR] = 1.04; P = 0.90), nor did the number of new mutations (SAT: 0.76 PPY, DAART: 0.83 PPY; adjusted RR = 0.99; P = 0.99) or the probability of developing new major IAS new drug mutations (SAT: 0.30 PPY, DAART: 0.33 PPY; adjusted RR = 1.12; P = 0.78). On measures of GSS and FDO, the 2 arms also did not differ. In this trial, DAART provided on-treatment virologic...Continue Reading

References

Aug 26, 1998·JAMA : the Journal of the American Medical Association·S A StrathdeeR S Hogg
Dec 28, 1999·Journal of Urban Health : Bulletin of the New York Academy of Medicine·B GreenbergD Vlahov
Jul 6, 2000·Annals of Internal Medicine·D L PatersonN Singh
Jul 13, 2001·JAMA : the Journal of the American Medical Association·M HermankovaD Persaud
Jul 21, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·G M LucasR D Moore
Jun 6, 2002·Journal of General Internal Medicine·Julia H ArnstenEllie E Schoenbaum
Jun 12, 2003·AIDS·Cheryl A Liechty, David R Bangsberg
Sep 27, 2003·The Journal of Infectious Diseases·Hongyu JiangVictor DeGruttola
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ajay K SethiJoel E Gallant
Mar 17, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I TinocoA Bascuñana
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Mar 27, 2004·The Journal of Antimicrobial Chemotherapy·David R BangsbergSteven G Deeks
Apr 21, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Heidi L BehforouzPaul E Farmer
Apr 30, 2004·HIV Clinical Trials·Thomas P GiordanoDavid R Bangsberg
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederick L AlticeGerald H Friedland
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brian ConwayStanley DeVlaming
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory M LucasRichard D Moore
Jun 15, 2004·The Journal of Infectious Diseases·David R BangsbergAndrew Moss
Jan 6, 2005·The Journal of Infectious Diseases·P Richard HarriganJulio S G Montaner
Mar 19, 2005·The Journal of Infectious Diseases·P Richard HarriganJulio S G Montaner
Jul 21, 2005·Journal of Medical Virology·Berta RodesUNKNOWN Red de Investigación en SIDA
Aug 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael J KozalGerald Friedland
Jun 17, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M B KushelD R Bangsberg
Jul 1, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·K Rivet AmicoJeffrey D Fisher
Aug 15, 2006·JAMA : the Journal of the American Medical Association·Jeffrey S A StringerMoses Sinkala
Aug 22, 2006·The Journal of Infectious Diseases·Robert W Shafer
Aug 31, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R Bangsberg
Sep 23, 2006·The Journal of Infectious Diseases·Robert GrossRobert S Hogg
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Duncan Smith-Rohrberg, Frederick L Altice
Oct 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hiroyu HatanoSteven G Deeks
Nov 30, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Duncan Smith-RohrbergFrederick L Altice
Aug 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederick L AlticeGerald H Friedland

❮ Previous
Next ❯

Citations

Jan 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Duncan Smith-Rohrberg MaruFrederick L Altice
Nov 10, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Curt G BeckwithJosiah D Rich
Apr 4, 2012·PloS One·Natasha E C G Davies, Alan S Karstaedt
Aug 17, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra A SpringerFrederick L Altice
Feb 24, 2010·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Sandra Ann SpringerFrederick L Altice

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.