Dirofilaria immitis: alteration of endothelium-dependent relaxation in the in vivo canine femoral artery

Experimental Parasitology
L KaiserJ F Williams

Abstract

Pathogenic mechanisms in filarial diseases are complex and poorly understood. While examining endothelium-dependent vasodilatory responses in the in vivo canine femoral artery, we noticed that dogs with Dirofilaria immitis infection had altered vascular responsiveness. The results reported here extend our original observations on vascular reactivity in dogs with D. immitis infection (L. Kaiser, J. F. Williams, E. A. Meade, and H. V. Sparks, 1987, American Journal of Physiology 253, H1325-H1329). In noninfected dogs, acetylcholine binds to the luminal endothelial cell muscarinic receptor. This results in release of a nonprostaglandin endothelium-derived relaxing factor. The relaxing factor causes an increase in vascular smooth muscle guanylate cyclase and relaxation. However, in dogs with D. immitis infection the mechanism of relaxation to acetylcholine is different. At least two endothelium derived relaxing factors are involved: the major factor is a prostaglandin; the second factor works through vascular smooth muscle cGMP. These data suggest that adult D. immitis release pharmacologically active factors that can alter distal endothelial cell function. The notion that filarial products may alter the physiological function of e...Continue Reading

References

Jan 1, 1985·Annual Review of Pharmacology and Toxicology·L J Ignarro, P J Kadowitz
Mar 1, 1987·Archives of Internal Medicine·L Kaiser, H V Sparks
Dec 1, 1985·The Journal of Infectious Diseases·D L LongworthP F Weller
Nov 1, 1985·Reviews of Infectious Diseases·C D MackenzieJ O'Day
Jan 1, 1984·Annual Review of Pharmacology and Toxicology·R F Furchgott
Jan 1, 1984·International Archives of Allergy and Applied Immunology·H G Johnson, M L McNee

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Citations

Jul 6, 2012·Clinical Microbiology Reviews·Fernando SimónJose Alberto Montoya-Alonso
Jul 8, 2008·Parasitology International·R MorchónF Simón
Jul 4, 2006·Journal of Molecular and Cellular Cardiology·Frank C ChenFrank V Brozovich
Mar 18, 2017·The Journal of Veterinary Medical Science·Katsuya KitohYasuhiro Takashima
Mar 21, 2019·Frontiers in Physiology·Paula Mariela GonzálezGeorgina A Rivera-Ingraham
Feb 1, 1997·Journal of Applied Physiology·M MupanomundaL Kaiser
Sep 1, 1995·Parasitology Today·A Belley, K Chadee
Dec 1, 1995·Microbiological Reviews·S L James

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