Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin

Veterinary Parasitology
Gad BanethShimon Harrus

Abstract

Therapy of canine dirofilariois due to Dirofilaria repens is indicated for dogs suffering from clinical signs of this disease, such as dermal swelling, sub-cutaneous nodules and pruritus. It is also important in order to decrease the risk of infection to other dogs and humans in the vicinity of the infected animal when suitable mosquito vectors are present. Combined therapy with the arsenic adulticide melarsomine and the avermectin microfilaricidal doramectin was effective in clearing infection with D. repens in a dog. The number of microfilariae dropped from 17 microl(-1) blood pre-treatment to 7 microl(-1) following the first adulticide injection and reached 0 a day after the microfilaricidal administration. The dog remained negative for D. repens microfilaremia during a follow-up period of 90 days. Euthanasia and necropsy performed 3 months after the initiation of therapy due to a progressive neoplastic disease revealed no evidence of filariae.

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Citations

Aug 6, 2000·Diagnostic Microbiology and Infectious Disease·G Favia
Mar 23, 2011·Vector Borne and Zoonotic Diseases·Claudio GenchiFrancesco Rivasi
Jan 18, 2013·Parasites & Vectors·Domenico OtrantoGioia Capelli
Jul 22, 2011·Veterinary Medicine International·Radmila Dobešová Paran, Vlasta Svobodová
Nov 30, 2013·Parasitology Research·Elisabetta GiudiceGiuseppe Mazzullo
Dec 21, 2006·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Katinka PónyaiSarolta Kárpáti
Nov 18, 2005·Veterinary Parasitology·Mark RishniwJose Luis Dominguez Alpizar
Mar 26, 2003·The Journal of Small Animal Practice·W Tarello
Jun 19, 2013·Veterinary Parasitology·Alessio GiannelliDomenico Otranto
Apr 15, 2020·Pathogens·Anatoly V KondrashinEvgeny N Morozov
Dec 21, 2018·Parasites & Vectors·Gioia CapelliCornelia Silaghi
Mar 29, 2019·Parasites & Vectors·Ricardo G Maggi, Friederike Krämer

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