PMID: 9163650May 1, 1997Paper

Disabling dyspnoea in patients with advanced disease: lack of effect of nebulized morphine

The European Respiratory Journal
A NosedaV de Maertelaer

Abstract

The purpose of this placebo-controlled, double-blind, randomized study was to assess the effect of nebulized morphine on dyspnoea perceived at rest by patients with advanced disease. Seventeen hospital in-patients with disabling dyspnoea received isotonic saline or morphine via nebulization for 10 min through a mouthpiece, combined with oxygen via nasal prongs. On four consecutive days, they were given one of the four following treatments in random order: saline with 2 L x min(-1) oxygen; 10 mg morphine with 2 L x min(-1) oxygen; 20 mg morphine with 2 L x min(-1) oxygen; and 10 mg morphine without oxygen (prongs fixed, no flow). Dyspnoea was assessed on a bipolar visual analogue scale (VAS) (-100% much more short of breath, +100% much less short of breath), and arterial oxygen saturation (Sa,O2) and respiratory frequency (fR) were recorded at the end of nebulization and 10 min later. In 14 subjects who completed the study, mean VAS ratings 10 min after the end of nebulization ranged +30 to +43%, with no significant difference between the four study days (VAS 20 mg morphine minus VAS saline, 95% confidence interval (95% CI) -6 to +8%). Sa,O2 significantly increased on the 3 days with supplemental oxygen, and remained stable on t...Continue Reading

Citations

Jan 25, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Raymond ViolaUNKNOWN Supportive Care Guidelines Group of the Cancer Care Ontario Program in Evidence-Based Care
Jun 28, 2000·Journal of Pain and Symptom Management·J P JanssensV Titelion
Feb 15, 2002·Journal of Pain and Symptom Management·Patrick J CoyneThomas J Smith
Apr 25, 2006·Journal of Palliative Medicine·Egidio Del FabbroEduardo Bruera
May 6, 2008·Journal of Palliative Medicine·Alberto A GaunaVincent Jay Vanston
May 15, 2002·The American Journal of Nursing·Christine Giska Westphal, Margaret L Campbell
Oct 13, 2006·The Cancer Journal·Cynthia M Williams
Jan 15, 2010·Current Opinion in Pulmonary Medicine·Basil Varkey
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Hope E UronisAmy P Abernethy
Sep 1, 2012·Acta Oncologica·Irit Ben-AharonSalomon M Stemmer
Feb 11, 2004·Chest·Pamela A ForalDaniel E Hilleman
Mar 13, 2012·International Journal of Nursing Studies·Rebecca T DislerPatricia M Davidson
Oct 31, 2006·Advanced Drug Delivery Reviews·Stephen J Farr, Babatunde A Otulana
Aug 13, 2002·Hematology/oncology Clinics of North America·Deborah J Dudgeon
May 9, 2003·Clinics in Geriatric Medicine·Laurie G Jacobs
Mar 25, 2015·Annals of the American Thoracic Society·Magnus EkströmDavid C Currow
Jun 11, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jackelyn Y BoydenJ Cameron Muir
May 18, 2004·Oncology Nursing Forum·Margaret JoyceJosephine Hawkins
May 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Irit Ben-AharonSalomon M Stemmer
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Anne Louise JenningsKaren E Broadley
Apr 21, 2005·The Annals of Pharmacotherapy·Sherrill J BrownJennifer R Jones
Sep 9, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Mary Beth ShirkJill Shirvani
Jul 9, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Titilola M AfolabiVinita Pai
Nov 24, 2017·The European Respiratory Journal·Cindy A VerberktDaisy J A Janssen
Mar 12, 2002·The American Journal of Hospice & Palliative Care·N SarhillM K Stahley
Mar 23, 1999·The American Journal of Hospice & Palliative Care·S Chandler
Apr 1, 2016·The Cochrane Database of Systematic Reviews·Hayley BarnesRenée Manser
Jul 26, 2002·The Cochrane Database of Systematic Reviews·R PolosaE H Walters
Apr 15, 2020·American Journal of Respiratory and Critical Care Medicine·Linda NiciShawn D Aaron
Feb 8, 2000·The American Journal of Hospice & Palliative Care·S Baumrucker
Apr 2, 2004·The American Journal of Hospice & Palliative Care·Steven J Baumrucker
Nov 26, 2016·The Cochrane Database of Systematic Reviews·Magnus EkströmDavid Currow
Sep 4, 2020·Annals of the American Thoracic Society·Eric J GartmanCarey C Thomson
Apr 23, 2021·Journal of Hospice and Palliative Nursing : JHPN : the Official Journal of the Hospice and Palliative Nurses Association·Margaret L CampbellLynn F Reinke

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