Disambiguating brain functional connectivity.

NeuroImage
Eugene P DuffM W Woolrich

Abstract

Functional connectivity (FC) analyses of correlations of neural activity are used extensively in neuroimaging and electrophysiology to gain insights into neural interactions. However, analyses assessing changes in correlation fail to distinguish effects produced by sources as different as changes in neural signal amplitudes or noise levels. This ambiguity substantially diminishes the value of FC for inferring system properties and clinical states. Network modelling approaches may avoid ambiguities, but require specific assumptions. We present an enhancement to FC analysis with improved specificity of inferences, minimal assumptions and no reduction in flexibility. The Additive Signal Change (ASC) approach characterizes FC changes into certain prevalent classes of signal change that involve the input of additional signal to existing activity. With FMRI data, the approach reveals a rich diversity of signal changes underlying measured changes in FC, suggesting that it could clarify our current understanding of FC changes in many contexts. The ASC method can also be used to disambiguate other measures of dependency, such as regression and coherence, providing a flexible tool for the analysis of neural data.

Citations

Feb 17, 2018·ELife·Janine Diane BijsterboschStephen M Smith
Apr 11, 2019·PloS One·Paulina KielibaTamar R Makin
Sep 11, 2019·Brain : a Journal of Neurology·Akira WibergDominic Furniss
Jul 16, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Corey HorienDustin Scheinost
Dec 10, 2019·Cerebral Cortex·Weihao ZhengTor D Wager
Aug 4, 2020·PLoS Computational Biology·Takuya ItoMichael W Cole
Jul 28, 2020·Brain Imaging and Behavior·Xin DiBharat B Biswal
Feb 12, 2020·Network Neuroscience·Daniel J LurieVince D Calhoun
Oct 28, 2020·Nature Neuroscience·Janine BijsterboschEugene P Duff
Mar 11, 2021·Network Neuroscience·Adam EichenbaumMark D'Esposito
Jun 28, 2021·Hearing Research·Elouise A Koops, Jos J Eggermont
Sep 2, 2021·NeuroImage·Janine D BijsterboschMatthew F Glasser

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA
dissection

Software Mentioned

MNE
LiNGAM
ASC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.