PMID: 3768397Nov 14, 1986Paper

Disappearance and effects of exogenous lipid transfer activity in rats

Biochimica Et Biophysica Acta
D W Quig, D B Zilversmit

Abstract

These studies were performed to determine the role of plasma lipid transfer activity in the regulation of plasma total and lipoprotein cholesterol in vivo. Partially purified human lipid transfer activity was injected into rats at a level similar to that of normal rabbit plasma, d greater than 1.21. The disappearance of exogenous lipid transfer activity from rat plasma was biphasic, with a 70% loss within 6 h. The remaining 30% was lost with a half-time of about 14 h. In the rat, short-term exposure (6 h) to high levels of lipid transfer activity resulted in a net transfer of cholesteryl esters from high density to d less than 1.019 lipoproteins, without affecting plasma total cholesterol. However, the lipid transfer activity-induced changes in lipoprotein cholesterol were not evident after 24 h, despite the fact that the lipid transfer activity of rat plasma d greater than 1.21 was similar to that of human plasma d greater than 1.21 during the preceding 18 h.

References

Dec 17, 1975·Biochimica Et Biophysica Acta·D B ZilversmitJ Balmer
Jan 1, 1976·Annals of the New York Academy of Sciences·H A Eder, P S Roheim
Sep 28, 1978·Biochimica Et Biophysica Acta·N M PattnaikD B Zilversmit
Nov 22, 1978·Biochimica Et Biophysica Acta·P J Barter, J I Lally
Feb 8, 1985·Biochimica Et Biophysica Acta·Y C HaP J Barter
Jan 26, 1981·Biochimica Et Biophysica Acta·R E Morton, D B Zilversmit

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Citations

Nov 30, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·A IglesiasM A Lasunción
Sep 1, 1994·Clinical and Experimental Pharmacology & Physiology·P Barter, K A Rye
Apr 1, 1988·Atherosclerosis·D W Quig, D B Zilversmit
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·L LagrostP Gambert
May 23, 1998·Biochimica Et Biophysica Acta·K H ChoY B Park
May 15, 1989·Biochimica Et Biophysica Acta·M Abbey, G D Calvert

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