PMID: 6159787Jan 1, 1980Paper

Disappearance of Hb F and i antigen during the first year of life

American Journal of Hematology
A HenriH Rochant

Abstract

In order to investigate whether a common control mechanism is involved in the diminution of i antigen expression and that of Hb F content in human erythrocytes during the postnatal period, we compared changes in 72 normal infants aged from 0 to 12 months. The proportion of hemoglobins (Hb F, Hb A, Hb A2) and the quantitation of "i" antigen were determined on the total population of red blood cells. In addition, the percentage of individual cells containing Hb F or "i" antigen or both (F cells, "i" cells, and F + "i" cells) were evaluated by using a rhodamine-conjugated anti-Hb F and a fluorescein conjugated anti-system on the same smear preparation. The results provided by the two most sensitive techniques (F cell counting and "i agglutinability) indicated that the curves of disappearance of Hb F and "i" antigen along the 12 first months after birth were identical. A strong correlation (r = 0.97, P < 0.0001) existed between the percentage of F cells and "i" antigen expression. In addition, the progressive increase in Hb A2 concentration was inversely correlated firstly with the proportion of Hb F and second with the expression of the "i" antigen. These results suggest that the switch from fetal to adult hemoglobin and the trans...Continue Reading

References

Jul 1, 1979·British Journal of Haematology·W VainchenkerJ Breton-Gorius
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T PapayannopoulouG Stamatoyannopoulos
Jun 1, 1978·British Journal of Haematology·B E SerjeantG R Serjeant
Jan 1, 1976·British Journal of Haematology·B ColomboL Terrenato
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H Fujii, A Yoshida
Jun 15, 1957·Klinische Wochenschrift·E KLEIHAUERK BETKE
Apr 1, 1961·British Journal of Haematology·W L MARSH
Dec 12, 1959·Nature·K BETKEI SCHLICHT

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Citations

Sep 19, 2015·Taiwanese Journal of Obstetrics & Gynecology·Wei-Lun ChengTai-Ping Lee
Jul 22, 2014·American Journal of Hematology·Paula J GriffinMartin H Steinberg
Jun 25, 2015·British Journal of Haematology·Martin H Steinberg, Griffin P Rodgers
May 31, 1990·Biochemical and Biophysical Research Communications·S NavarroJ Doly
Mar 1, 1984·British Journal of Haematology·L FelicettiB Colombo
Aug 1, 1996·European Journal of Haematology·D C MaW Zuo
Feb 26, 2021·Current Opinion in Hematology·Eugene Khandros, Gerd A Blobel

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