PMID: 7334361Jan 1, 1981Paper

Disappearance of hepatitis B surface antigen during an unusual case of fulminant hepatitis B

Journal of Medical Virology
E TaborR J Gerety

Abstract

A 30-year-old surgical resident was admitted to the hospital with symptoms of acute hepatitis; two days later he became comatose. Hepatitis B surface antigen had been detected in his serum two days prior to admission, but it was not detected at any time thereafter. Hepatitis B e antigen, antibody to hepatitis B core antigen, and antibody to hepatitis B surface antigen were detected using sensitive radioimmunoassays at admission. Titers of antibody to hepatitis B core antigen increased over the next five weeks. Clearance of hepatitis B e antigen and subsequent appearance of antibody to hepatitis B e antigen accompanied clinical improvement and recovery. This unusual case documents that hepatitis B surface antigen can become undetectable during the course of fulminant hepatitis B and indicates the importance of tests for other serologic markers of hepatitis B virus in the evaluation of hepatitis B surface antigen-negative fulminant hepatitis.

References

Nov 1, 1979·Transfusion·E Tabor, R J Gerety
Jul 1, 1977·Annals of Internal Medicine·J H HoofnagleR H Purcell
Jul 1, 1977·Annals of Internal Medicine·J D MeyersK K Holmes
Jan 1, 1979·The Journal of Infectious Diseases·R H DeckerJ Boggs
Jun 1, 1979·The Journal of Infectious Diseases·B GuyerJ E Maynard
Feb 23, 1978·The New England Journal of Medicine·T AikawaM Mayumi
Jan 1, 1978·Journal of Medical Virology·I K MushahwarC M Ling
Sep 18, 1976·British Medical Journal·I L WoolfA J Zuckerman
Oct 20, 1973·Lancet·J H HoofnagleL F Barker
Mar 1, 1980·The Journal of Infectious Diseases·E TaborR J Gerety

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Citations

Apr 2, 1983·Lancet·E TaborR J Gerety
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A R NeurathS Krugman
Jan 1, 1988·Scandinavian Journal of Infectious Diseases·K KrogsgaardL Ranek

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