PMID: 7020317Jul 1, 1981Paper

Disappearance of insulin in man: variation with the plasma insulin level

Acta Endocrinologica
K G TranbergJ Thorell

Abstract

Clearance rates of unlabelled insulin were studied in 45 unanaesthetized non-diabetic humans. The clearance rate, as well as the pancreatic secretion rate, of endogenous insulin was estimated from steady-state concentrations in portal and arterial blood. The clearance rate of exogenous insulin was determined after brief intraportal infusion. In the basal fasting state, the endogenous plasma insulin level varied as closely with the clearance of endogenous insulin as with the rate of pancreatic secretion. During elevation of insulin by glucose infusion, it varied predominantly with the rate of insulin secretion. Clearance of exogenous insulin did not vary with the pre-test endogenous insulin level. The clearance of endogenous insulin increased form 11 ml . min-1 . kg-1 in the basal fasting state to 17 ml . min-1. kg-1 during glucose infusion. Clearance of exogenous insulin fell progressively with increasing dose, form 35 (8 mU/kg) to 14 (43 mU/kg) ml . min-1 . kg-1 at normoglycaemia and 23 (8 mU/kg) to 17 (34 mU/kg) ml . min-1 . kg-1 at hyperglycaemia. The clearance of endogenous insulin was lower than that of exogenous insulin at normoglycaemia, but of similar size during glucose infusion. It is concluded that variation in clear...Continue Reading

Citations

Jan 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·J W Truran
Jun 5, 2007·Computer Methods and Programs in Biomedicine·Jessica LinChristopher E Hann
Dec 18, 2004·Medical Engineering & Physics·J Geoffrey ChaseBob Broughton

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