Disappearance of supra-ependymal 5-HT axons in the rat forebrain after electrolytic and 5,6-DHT-induced lesions of the medial forebrain bundle.

Brain Research
H LorezJ G Richards

Abstract

The present study was intended to demonstrate the origin of supra-ependymal 5-hydroxytryptamine axons in the rat forebrain. Electrolytic lesions and injections of 5,6-dihydroxytryptamine (10 mug in 4 mul) were carried out unilaterally in and close to the medial forebrain bundle in the posterior hypothalamus of rats. Ten to 14 days later, terminal axons and formaldehyde-induced indolealkylamine fluorescence had virtually disappeared supra-ependymally in the lateral ventricles and interventricular foramina ipsilateral to the lesion if the indolealkylamine axons passing through the medial part of the medial forebrain bundle had been destroyed. No changes were observed, electron microscopically or fluorescence histochemically, in ventricles contralateral to the lesion. It is concluded that the supra-ependymal serotonergic nerve terminals in the lateral ventricles and interventricular foramina originate, uncrossed, from non-terminal axons passing through the medial forebrain bundle in the posterior hypothalamus.

References

Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Nov 15, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·H P Lorez, J G Richards
Dec 21, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·A BjörklundU Stenevi
Oct 1, 1953·Journal of Neuropathology and Experimental Neurology·H KLUVER, E BARRERA

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Citations

Jan 1, 1983·Anatomy and Embryology·P Martinez Martinez, H de Weerd
Dec 28, 1977·Anatomy and Embryology·R N Cupédo
Apr 1, 1994·Neuroscience·B VoutsinosM Didier-Bazes
Jan 1, 1986·Law, Medicine & Health Care : a Publication of the American Society of Law & Medicine·N Hershey
Jan 1, 1983·British Journal of Clinical Pharmacology·J M Gaillard

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