DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort.

PloS One
Liisa TomppoWilliam Hennah

Abstract

Genetic evidence implicates the DISC1 gene in the etiology of a number of mental illnesses. Previously, we have reported association between DISC1 and measures of psychosis proneness, the Revised Social Anhedonia Scale (RSAS) and Revised Physical Anhedonia Scale (RPAS), in the Northern Finland Birth Cohort 1966 (NFBC66). As part of the studies of this Finnish birth cohort genome-wide association analysis has recently been performed. In the present study, we re-analyzed the genome-wide association data with regard to these two measures of psychosis proneness, conditioning on our previous DISC1 observation. From the original NFBC66 sample (N = 12 058), 4 561 individuals provided phenotype and genotype data. No markers were significant at the genome-wide level. However, several genes with biological relevance to mental illnesses were highlighted through loci displaying suggestive evidence for association (≥3 SNP with P<10E-4). These included the protein coding genes, CXCL3, KIAA1128, LCT, MED13L, TMCO7, TTN, and the micro RNA MIR620. By conditioning a previous genome-wide association study on DISC1, we have been able to identify eight genes as associating to psychosis proneness. Further, these molecules predominantly link to the D...Continue Reading

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Citations

Jun 20, 2015·Schizophrenia Research and Treatment·Erika JääskeläinenJouko Miettunen
May 20, 2017·Schizophrenia Bulletin·Alfredo Ortega-AlonsoWilliam Hennah
Jan 21, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David St Clair, Mandy Johnstone
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Oct 16, 2019·The Journal of Physical Chemistry. B·Julien Roche, Davit A Potoyan

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Methods Mentioned

BETA
in silico techniques
genotyping

Software Mentioned

SZGene
PLINK
MicroCosm
UCSC Genome Browser
Haploview
IPA

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