PMID: 11914473Mar 27, 2002Paper

Discerning malignancy in resected adrenocortical neoplasms

Endocrine Pathology
H SasanoTakuya Moriya

Abstract

Differential diagnosis between adenoma and carcinoma in resected human adrenocortical neoplasms may be one of the most problematic and difficult areas of surgical pathology practice. This is especially true in cases of relatively small adrenocortical tumors not associated with obvious signs of malignancy such as necrosis and/or hemorrhage. In addition, the numbers of these small adrenocortical neoplasms are increasing owing to the widespread application of sophisticated computed tomography and/or magnetic resonance imaging scans. No single parameter can be effective in this differential diagnosis of resected adrenocortical tumor. Histopathologic evaluation using a multivariate scoring system is considered most effective in discerning malignancy and biologic behavior of resected adrenocortical neoplasms. Molecular and cellular findings of adrenocortical carcinoma have been inconsistent except for the increased cell proliferation associated with adrenocortical malignancy. Therefore, an assessment of neoplastic cell proliferation using immunostains of cell cycle-associated nuclear antigen such as Ki-67 is the only useful auxiliary method of evaluating malignancy in resected adrenocortical neoplasms at present.

Citations

Dec 18, 2008·Endocrine Pathology·Anne Marie McNicol
May 20, 2004·European Urology·M ScarpelliUNKNOWN Uropathology Working Group, European Society of Pathology
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas J GiordanoGary Hammer
Mar 25, 2004·AJR. American Journal of Roentgenology·Sean D PaulsenEllen J Higgins
Oct 1, 2008·Expert Opinion on Medical Diagnostics·Sasano HironobuNakamura Yasuhiro
Dec 14, 2004·World Journal of Surgery·Libuse TauchmanovàRiccardo Rossi
Dec 1, 2018·Acta chirurgica Belgica·Loncar ZlatiborVladimir Djukic
Aug 8, 2008·Archives of Pathology & Laboratory Medicine·Anne Marie McNicol

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