Discharge modulation of rat dorsal raphe neurons during sleep and waking: effects of preoptic/basal forebrain warming

Brain Research
Ruben Guzman-MarinDennis McGinty


In cats, putative serotonergic neurons (PSNs) recorded from the dorsal raphe nucleus (DRN) across the sleep-wake cycle exhibit the so-called rapid eye movement sleep-off (REM-off) discharge pattern. Since, the sleep-wake discharge patterns of DRN neurons in behaving rats is poorly known, the present study examined this neuronal populations. The PSNs recorded in this study exhibited: (1) progressive decrease in discharge rate from waking to NREM to REM sleep; (2) long action potential duration, and (3) reduction of discharge rate after systemic administration of a selective 5-HT(1A) agonist, (+/-)-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide (8-OH-DPAT). Evidence supports the hypothesis that NREM sleep is modulated by thermoregulatory mechanisms localized in the preoptic area and adjacent basal forebrain (POA/BF). We previously reported that POA/BF warming suppresses the discharge of wake-promoting neurons in the posterior hypothalamus and the basal forebrain. Since the DRN is one component of the brainstem arousal system and receives projections from POA/BF, we examined the effects of local POA/BF warming by 1.5-2.0 degrees C during waking on the discharge of DRN neurons. POA/BF warming reduced the discharge in 14 of 19...Continue Reading


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Feb 26, 2015·ELife·Jeremiah Y CohenNaoshige Uchida
Oct 31, 2019·Current Sleep Medicine Reports·James C DooleyMark S Blumberg
May 21, 2019·Frontiers in Neuroscience·Edward C HardingWilliam Wisden
Jul 2, 2008·Annals of the New York Academy of Sciences·Ronald Szymusiak, Dennis McGinty

Related Concepts

Surface Electromyography
Entire Brainstem
Reaction Time
Projections and Predictions
Sleep, Slow-Wave
Preoptic Areas
Action Potentials
Hot Temperature

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