Discharge modulation of rat dorsal raphe neurons during sleep and waking: effects of preoptic/basal forebrain warming

Brain Research
Ruben Guzman-MarinDennis McGinty

Abstract

In cats, putative serotonergic neurons (PSNs) recorded from the dorsal raphe nucleus (DRN) across the sleep-wake cycle exhibit the so-called rapid eye movement sleep-off (REM-off) discharge pattern. Since, the sleep-wake discharge patterns of DRN neurons in behaving rats is poorly known, the present study examined this neuronal populations. The PSNs recorded in this study exhibited: (1) progressive decrease in discharge rate from waking to NREM to REM sleep; (2) long action potential duration, and (3) reduction of discharge rate after systemic administration of a selective 5-HT(1A) agonist, (+/-)-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide (8-OH-DPAT). Evidence supports the hypothesis that NREM sleep is modulated by thermoregulatory mechanisms localized in the preoptic area and adjacent basal forebrain (POA/BF). We previously reported that POA/BF warming suppresses the discharge of wake-promoting neurons in the posterior hypothalamus and the basal forebrain. Since the DRN is one component of the brainstem arousal system and receives projections from POA/BF, we examined the effects of local POA/BF warming by 1.5-2.0 degrees C during waking on the discharge of DRN neurons. POA/BF warming reduced the discharge in 14 of 19...Continue Reading

References

Sep 3, 2002·The Journal of Physiology·Natalia SuntsovaDennis McGinty
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hui GongDennis McGinty
Apr 4, 2003·Journal of Physiological Anthropology and Applied Human Science·Suchinda JarupatAlicja Borkiewicz
Feb 27, 2008·Journal of Pineal Research·R V RialS Esteban
Jul 5, 2007·Genes, Brain, and Behavior·Victoria F TurekAndrey E Ryabinin
Apr 23, 2008·Current Protocols in Neuroscience·Ronald Szymusiak, Douglas Nitz
Jan 16, 2002·The Journal of Physiology·Md Noor AlamRonald Szymusiak
Jan 24, 2007·The European Journal of Neuroscience·Sunil KumarMd Noor Alam
Feb 26, 2015·ELife·Jeremiah Y CohenNaoshige Uchida
Oct 31, 2019·Current Sleep Medicine Reports·James C DooleyMark S Blumberg
May 21, 2019·Frontiers in Neuroscience·Edward C HardingWilliam Wisden
Jul 2, 2008·Annals of the New York Academy of Sciences·Ronald Szymusiak, Dennis McGinty

Related Concepts

Surface Electromyography
Entire Brainstem
Reaction Time
Projections and Predictions
Sleep, Slow-Wave
Neurons
Serotonin
Preoptic Areas
Action Potentials
Hot Temperature

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.