Discharge patterns of hypoglossal motoneurons during fictive breathing, coughing, and swallowing

Journal of Neurophysiology
Fabrice RodaA L Bianchi

Abstract

We performed a series of experiments to study the intracellular activity of 58 hypoglossal motoneurons (HMs) in decerebrate, paralyzed, and ventilated cats. Changes in membrane potentials (MP) and discharge activities were evaluated during fictive breathing (FB), swallowing (FS), and coughing (FC). FS and FC were elicited by electrical stimulation of the superior laryngeal nerves. FB, FS, and FC all exhibited characteristic discharge patterns of the phrenic, abdominal, pharyngeal branch of the vagus, and hypoglossal nerves. Thirty-nine HMs displayed respiratory modulation, and 19 were nonrespiratory modulated. Nine HMs did not exhibit MP changes during FB, FS, and FC. During FS, 49 HMs exhibited MP changes consisting of depolarization, hyperpolarization or hyperpolarization-depolarization. HMs involved in FS were either respiratory modulated (n = 38) or not (n = 11). Only 20 HMs displayed MP changes and/or discharge activity during FC. All but two HMs fired during the expiratory phase of FC or at the end of this reflex. All HMs involved in FC (n = 20) were also modulated during both FB and FS. Our results suggest that the XII nucleus is functionally divided into common and distinct subsets of HMs based on their spontaneous acti...Continue Reading

References

Sep 1, 1992·Journal of Applied Physiology·E van Lunteren, T E Dick
Aug 1, 1992·Canadian Journal of Physiology and Pharmacology·S Iscoe, L Grélot
May 1, 1992·Journal of Neurophysiology·J B Travers, L M Jackson
Dec 1, 1991·Journal of Applied Physiology·D C Bolser
Apr 1, 1988·Journal of Applied Physiology·J S Jodkowski, A J Berger
Jun 1, 1988·Neuroscience·D J Withington-WrayK M Spyer
Jan 1, 1985·Experimental Brain Research·J P Kessler, A Jean
May 1, 1985·Respiration Physiology·M BonoraS L Knuth
Nov 1, 1983·The Journal of Comparative Neurology·J B Travers, R Norgren
Aug 1, 1984·The American Review of Respiratory Disease·M BonoraW M St John
Sep 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J C HwangD Bartlett
Sep 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J C HwangW M St John
Jan 1, 1980·Progress in Neurobiology·A A Lowe
Jul 3, 1995·The Journal of Comparative Neurology·E G Dobbins, J L Feldman
Sep 1, 1994·Journal of Neurophysiology·L A Dinardo, J B Travers
Sep 1, 1994·Journal of Neurophysiology·S P ZhangP Carrive
Jun 1, 1993·The Journal of Physiology·T E DickN S Cherniack
Aug 1, 1993·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·S AdachiJ A Fleetham
Oct 1, 1996·The American Journal of Physiology·F Hayashi, D R McCrimmon
Oct 1, 1996·Pulmonary Pharmacology·R ShannonB G Lindsey
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·J B TraversH Karimnamazi
Jan 4, 1998·Respiration Physiology·R F Fregosi, D D Fuller
Feb 11, 1998·The Journal of Physiology·O PierreficheK M Spyer
Mar 21, 1998·The Journal of Experimental Zoology·A J ThextonR Z German
Jun 11, 1998·Journal of Applied Physiology·R ShannonB G Lindsey
Dec 19, 1998·Neuroscience Research·I SatohA Konno

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Citations

Dec 19, 2008·Journal of Neurophysiology·Antonio SanchezEckehard A E Stuth
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Walter M St John
Oct 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ana P L AbdalaJulian F R Paton
May 2, 2009·Respiratory Physiology & Neurobiology·Armand L Bianchi, Christian Gestreau
Sep 15, 2004·Experimental Physiology·Walter M St-JohnJ C Leiter
May 28, 2005·Respiratory Physiology & Neurobiology·Christian GestreauArmand Louis Bianchi
Dec 23, 2003·The Journal of Comparative Neurology·Fabrice RodaChristian Gestreau
Jul 24, 2020·International Journal of Molecular Sciences·Victor Bergé-Laval, Christian Gestreau
Apr 25, 2020·Frontiers in Human Neuroscience·Suzanne N KingTeresa Pitts
Jul 31, 2020·Journal of Neurophysiology·Toshiro UmezakiYoichiro Sugiyama
Feb 1, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Anna M LavezziLuigi Matturri
Jul 22, 2017·Frontiers in Neurology·Riffat MehboobFridoon Jawad Ahmad
Jul 18, 2018·Frontiers in Physiology·Kofi-Kermit HortonChristian Gestreau
Jul 30, 2021·Journal of Applied Physiology·Matthew J Fogarty, Gary C Sieck

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