Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study

PloS One
Andrea MikeZsolt Illes

Abstract

Successful socialization requires the ability of understanding of others' mental states. This ability called as mentalization (Theory of Mind) may become deficient and contribute to everyday life difficulties in multiple sclerosis. We aimed to explore the impact of brain pathology on mentalization performance in multiple sclerosis. Mentalization performance of 49 patients with multiple sclerosis was compared to 24 age- and gender matched healthy controls. T1- and T2-weighted three-dimensional brain MRI images were acquired at 3Tesla from patients with multiple sclerosis and 18 gender- and age matched healthy controls. We assessed overall brain cortical thickness in patients with multiple sclerosis and the scanned healthy controls, and measured the total and regional T1 and T2 white matter lesion volumes in patients with multiple sclerosis. Performances in tests of recognition of mental states and emotions from facial expressions and eye gazes correlated with both total T1-lesion load and regional T1-lesion load of association fiber tracts interconnecting cortical regions related to visual and emotion processing (genu and splenium of corpus callosum, right inferior longitudinal fasciculus, right inferior fronto-occipital fascicu...Continue Reading

References

Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Nov 6, 1998·Journal of Cognitive Neuroscience·V E StoneR T Knight
Sep 9, 1999·Journal of Autism and Developmental Disorders·J Craig, S Baron-Cohen
Dec 10, 1999·Journal of Autism and Developmental Disorders·S Baron-CohenK Plaisted
May 29, 2000·Trends in Cognitive Sciences·J V HaxbyM I Gobbini
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Feb 13, 2001·The European Journal of Neuroscience·G BuccinoH J Freund
Mar 31, 2001·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Baron-CohenI Plumb
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Jan 22, 2002·Biological Psychiatry·James V HaxbyM Ida Gobbini
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Dec 24, 2002·Journal of Cognitive Neuroscience·Ralph AdolphsDaniel Tranel
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Laurie CarrGian Luigi Lenzi
Jun 25, 2003·Brain : a Journal of Neurology·Marco CataniDominic H Ffytche
Sep 10, 2003·Archives of General Psychiatry·Gina R KuperbergBruce Fischl
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
Feb 26, 2004·NeuroImage·Kenneth R LeslieScott T Grafton
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Jun 26, 2004·Annual Review of Neuroscience·Giacomo Rizzolatti, Laila Craighero
May 25, 2005·Neuropsychology·S G Shamay-TsooryJ Aharon-Peretz
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
May 17, 2006·Neuron·Chris D Frith, Uta Frith
Sep 20, 2006·Journal of the International Neuropsychological Society : JINS·Ralph H B BenedictBianca Weinstock-Guttman
Nov 30, 2006·Human Brain Mapping·Hae-Jeong ParkJong Doo Lee
Nov 8, 2007·Multiple Sclerosis : Clinical and Laboratory Research·Mm SummersMa Ron
Nov 15, 2008·Lancet Neurology·Nancy D Chiaravalloti, John DeLuca
Feb 11, 2009·Journal of the International Neuropsychological Society : JINS·Julie D HenryPeter G Rendell
Apr 11, 2009·Autism Research : Official Journal of the International Society for Autism Research·Justin H G Williams
Jul 22, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J A C J BastiaansenC Keysers
Aug 19, 2009·Behavioural Brain Research·Matthias KrauseMartin Lotze
Nov 20, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M BanatiZ Illes
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carissa L PhilippiDavid Rudrauf
Feb 18, 2010·Social Neuroscience·Scott H SymingtonWarren S Brown
Feb 20, 2010·Journal of the International Neuropsychological Society : JINS·Julie OuelletPierre Duquette
Apr 20, 2010·Clinical Neurology and Neurosurgery·Margit JehnaChristian Enzinger
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jamil ZakiKevin N Ochsner
Oct 15, 2010·Social Neuroscience·Martin Schulte-RütherMartina Piefke
Oct 19, 2010·NeuroImage·Dean SabatinelliJoshua Jeffries

❮ Previous
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Citations

Nov 7, 2014·Journal of the International Neuropsychological Society : JINS·Cinzia CecchettoRaffaella Ida Rumiati
Feb 15, 2015·Social Cognitive and Affective Neuroscience·Clare M Eddy, Hugh E Rickards
Sep 17, 2014·Social Neuroscience·Helen M GenovaJeannie Lengenfelder
Oct 23, 2016·BMC Neurology·Olivia GeisselerMichael Linnebank
Oct 7, 2016·Social Neuroscience·Agustín IbáñezFacundo Manes
May 27, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Miklos PalotaiCharles Rg Guttmann
Feb 17, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Noa FingherEric Courchesne
Sep 13, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M NeuhausI-K Penner
Jul 8, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jana KynastMatthias L Schroeter
Jan 11, 2017·Journal of the International Neuropsychological Society : JINS·Moussa A Chalah, Samar S Ayache
Nov 26, 2015·Journal of the International Neuropsychological Society : JINS·Helen M GenovaJean Lengenfelder
Jan 18, 2020·Journal of the International Neuropsychological Society : JINS·Helen M Genova, Skye McDonald
May 8, 2020·Social Neuroscience·Sara IserniaFrancesca Baglio
Nov 21, 2018·Behavioral Sciences·Samar S Ayache, Moussa A Chalah
Mar 3, 2020·Frontiers in Behavioral Neuroscience·Alvino BiseccoAntonio Gallo
Jul 17, 2020·Frontiers in Neurology·Sabrina GoldeStefan M Gold
Jun 22, 2016·Neuropsychology Review·Emre BoraMark Walterfang
Mar 22, 2019·Biomedicines·Miguel Ángel Macías Islas, Ethel Ciampi
Jun 5, 2020·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Moussa A Chalah, Samar S Ayache
Mar 10, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Sonia BatistaLuís Cunha
Oct 28, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Andreas JohnenSven G Meuth
Oct 7, 2019·Annals of Physical and Rehabilitation Medicine·Céline ChanialCéline Borg
Apr 10, 2018·Trends in Cognitive Sciences·Yin Wang, Ingrid R Olson
Apr 17, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Line PfaffFrédéric Blanc
Apr 27, 2021·Frontiers in Psychiatry·XiaoGuang LinZhongQuan Yi
May 8, 2021·Multiple Sclerosis and Related Disorders·XiaoGuang LinZhongQuan Yi
Aug 1, 2021·Multiple Sclerosis and Related Disorders·Hiroaki YokoteShuta Toru
Oct 24, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Ornella ArgentoValerio Pisani
Nov 20, 2021·Journal of Neuroscience Research·Ismail KoubiyrAurélie Ruet

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Software Mentioned

FMRIB Linear Image Registration Tool ( FLIRT )
SPSS
FreeSurfer
MPRAGE
Non Image Registration Tool
FMRIB
Brain Extraction Tool
3D
Slicer

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