Discontinuation of anti-tumor necrosis factor therapy in inflammatory bowel disease patients: a prospective observation

Scandinavian Journal of Gastroenterology
Martin BortlikMilan Lukas

Abstract

Discontinuation of anti-TNF therapy in patients with inflammatory bowel diseases (IBD) in remission remains a controversial issue. The aims of our study were to assess the proportion of patients who relapse after cessation of biological treatment, and to identify potential risk factors of disease relapse. Consecutive IBD patients who discontinued anti-TNF therapy in steroid-free clinical and endoscopic remission were prospectively followed. Multiple logistic regression and Cox proportional-hazards models were used to assess the predictors of disease relapse. Seventy-eight IBD patients (Crohn's disease, CD 61; ulcerative colitis, UC 17) were included and followed for a median of 30 months (range 7-47). A total of 32 (53%) CD patients and nine (53%) UC patients relapsed by the end of the follow-up with a median time to relapse of 8 months (range 1-25) in CD patients and 14 months (range 4-37) in UC patients, respectively. The cumulative probabilities of maintaining remission at 6, 12, and 24 months were 82%, 59%, and 51% in CD patients, and 77%, 77%, and 64% in UC patients, respectively. Survival of CD patients who were in deep remission (clinical and endoscopic healing; faecal calprotectin <150 mg/kg; CRP ≤5 mg/l) was not better...Continue Reading

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Citations

Apr 5, 2016·Expert Review of Gastroenterology & Hepatology·Guillaume Pineton de ChambrunLaurent Peyrin-Biroulet
Oct 11, 2016·Gastroenterology·Jean-Frederic ColombelLaurent Peyrin-Biroulet
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Mar 12, 2019·Alimentary Pharmacology & Therapeutics·Fabiana CastiglioneAntonio Rispo
Nov 12, 2019·Journal of Crohn's & Colitis·Joana TorresGionata Fiorino
May 8, 2018·Inflammatory Bowel Diseases·Clémence LeguéGuillaume Bouguen
Mar 13, 2019·Clinical Pharmacology and Therapeutics·Antoine PetitcollinÉric Bellissant
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