Discontinuation of disease-modifying therapy for patients with relapsing-remitting multiple sclerosis: Effect on clinical and MRI outcomes

Multiple Sclerosis and Related Disorders
Hajime YanoTanuja Chitnis

Abstract

Disease-modifying therapy (DMT) for patients with relapsing-remitting multiple sclerosis (RRMS) have been shown to reduce relapses and new MRI lesions. However, few studies have assessed the impact of discontinuing DMT after a period of disease inactivity. To investigate the impact of DMT discontinuation on clinical and radiological outcomes in RRMS patients. 69 RRMS patients who discontinued DMT after a period of disease inactivity were identified from the Comprehensive Longitudinal Investigation of MS study at the Brigham and Women's Hospital, based on the following inclusion criteria: age 18 or older; treated with DMT ≥2 years; no clinical and radiological relapse ≥2 years until the discontinuation; not restarting DMT for ≥6 months after discontinuation. Patients matched by age, gender, treatment, treatment duration, disease duration and Expanded Disability Status Scale score who remained on DMT were identified. Univariate and multivariable Cox proportional hazard models with robust standard errors to account for the paired data were used to test the differences based on DMT discontinuation with the outcome measures: time to clinical relapse, MRI event, disability progression, and disease activity (either clinical relapse or...Continue Reading

Citations

Dec 29, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Gabriel BstehThomas Berger
Nov 4, 2020·Multiple Sclerosis and Related Disorders·Matteo PascaAnna Maria Repice
Mar 23, 2021·Annals of Clinical and Translational Neurology·Annette Langer-GouldAllen S Nielsen
Feb 10, 2021·Neurology. Neuroimmunology and Neuroinflammation·Derek McFaulAnnette Langer-Gould
Apr 20, 2021·Therapeutic Advances in Neurological Disorders·Yinan ZhangOlaf Stuve
May 15, 2021·Current Opinion in Neurology·Hans-Peter HartungGiancarlo Comi

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