Discontinuous Dewetting in a Degassed Mold for Fabrication of Homogeneous Polymeric Microparticles

ACS Applied Materials & Interfaces
Hyeon Ung KimKi Wan Bong

Abstract

Discontinuous dewetting (DD) is an attractive technique that enables the production of large liquid arrays in microwells and is applicable to the synthesis of anisotropic microparticles with complex morphologies. However, such loading of liquids into microwells presents a significant challenge, as the liquids used in this technique should exhibit low mold surface wettability. This study introduces DD in a degassed mold (DM), a simple yet powerful technique that achieves uniform loading of microparticle precursors into large microwell arrays within 1 min. Using this technique, hydrogel microparticles are produced by different polymerization mechanisms with various shapes and sizes, ranging from a few micrometers to hundreds of micrometers. Hydrophobic oil microparticles are produced by the simple plasma treatment of the DM, and agarose microparticles encapsulating bovine serum albumin (in a well-dispersed state) are produced by submerging the DM in fluorinated oil. To demonstrate additional functionality of microparticles using this technique, high concentrations of magnetic nanoparticles are loaded into microparticles for particle-based immunoassays performed in a microwell plate, and the immunoassay performance is comparable t...Continue Reading

References

Jul 14, 2005·Journal of the American Chemical Society·Jason P RollandJoseph M DeSimone
Mar 10, 2007·Science·Daniel C PregibonPatrick S Doyle
Feb 25, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Ki Wan BongPatrick S Doyle
Aug 6, 2010·Biomaterials·Katrin BottSimone C Rizzi
Aug 24, 2010·Nature Materials·Howon LeeSunghoon Kwon
Sep 28, 2010·Nature Nanotechnology·Jae K HwangMyung M Sung
Jul 30, 2011·Biomicrofluidics·Zhi-Xiao GuoXing-Zhong Zhao
Sep 29, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Su Kyung SuhPatrick S Doyle
Oct 22, 2011·Nature Protocols·David C AppleyardPatrick S Doyle
Apr 6, 2012·Journal of the American Chemical Society·Stuart S DunnJoseph M DeSimone
May 1, 2013·PloS One·Patricia PachecoTodd Sulchek
May 15, 2013·Angewandte Chemie·Jing XuJoseph M DeSimone
Feb 26, 2016·Molecular Pharmaceutics·Yuanzu He, Kinam Park
Feb 27, 2016·Advanced Materials·Wenqian FengPavel A Levkin
May 4, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Martina TakacovaSilvia Pastorekova
May 2, 2017·Carbohydrate Polymers·Lissette AgüeroMarcos L Dias
Sep 26, 2017·ACS Applied Materials & Interfaces·Michael E DeagenChaitanya K Ullal
Sep 30, 2017·Nature Communications·Seunggun YuChong Min Koo
Feb 11, 2018·Nature Communications·Sebastián L VegaJason A Burdick
Mar 1, 2018·Carbohydrate Polymers·Payam ZarrintajMasoud Mozafari
Apr 30, 2019·Small·Marcel Alexander HeinrichYu Shrike Zhang
Nov 8, 2019·ACS Applied Materials & Interfaces·Jong Bin KimShin-Hyun Kim
Jan 25, 2020·Journal of Clinical Medicine·Nak Jun LeeKi Wan Bong
Jan 1, 2020·Nature Reviews. Materials·Andrew C DalyJason A Burdick

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
Aaron F Orozco, Dorothy E Lewis
Arteriosclerosis, Thrombosis, and Vascular Biology
Chantal M Boulanger, Françoise Dignat-George
Methods in Molecular Biology
S Nomura, Shirou Fukuhara
Blood Cells, Molecules & Diseases
Seongcheol KimPudur Jagadeeswaran
© 2021 Meta ULC. All rights reserved