Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification: The CARDIA Study.

Journal of the American College of Cardiology
John T WilkinsDonald M Lloyd-Jones

Abstract

High levels of apolipoprotein B (apoB) have been shown to predict atherosclerotic cardiovascular disease (CVD) in adults even in the context of low levels of low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (non-HDL-C). This study aimed to quantify the associations between apoB and the discordance between apoB and LDL-C or non-HDL-C in young adults and measured coronary artery calcium (CAC) in midlife. Data were derived from a multicenter cohort study of young adults recruited at ages 18 to 30 years. All participants with complete baseline CVD risk factor data, including apoB and year 25 (Y25) CAC score, were entered into this study. Presence of CAC was defined as having a positive, nonzero Agatston score as determined by computed tomography. Baseline apoB values were divided into tertiles of 4 mutually exclusive concordant/discordant groups, based on median apoB and LDL-C or non-HDL-C. Analysis included 2,794 participants (mean age: 25 ± 3.6 years; body mass index: 24.5 ± 5 kg/m(2); and 44.4% male). Mean lipid values were as follows: total cholesterol: 177.3 ± 33.1 mg/dl; LDL-C: 109.9 ± 31.1 mg/dl; non-HDL-C: 124.0 ± 33.5 mg/dl; HDL-C: 53 ± 12.8 mg/dl; and apoB: 90.7 ± 24 mg/dl; median tr...Continue Reading

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Citations

Jun 25, 2016·Journal of the American College of Cardiology·Altan OnatYusuf Karadeniz
Nov 26, 2016·Clinics in Geriatric Medicine·Rachel H MackeyLarry W Moreland
Jun 25, 2016·Journal of the American College of Cardiology·John T WilkinsDonald M Lloyd-Jones
May 11, 2018·Clinical Cardiology·Jay KhambhatiLaurence S Sperling
May 22, 2019·JAMA : the Journal of the American Medical Association·Amanda M PerakDonald M Lloyd-Jones
Oct 24, 2019·JAMA Cardiology·Allan D SnidermanBrian A Ference
Aug 30, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Emma J AkersBelinda A Di Bartolo
May 16, 2018·Clinical Chemistry·Michel R LangloisUNKNOWN European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Join
Dec 3, 2016·Postgraduate Medical Journal·Bradley Field BaleDavid John Vigerust
Aug 15, 2019·Scientific Reports·Sílvia ParedesIsabel Palma
Aug 9, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M C BoddeJ W Jukema
Jun 13, 2020·Frontiers in Cardiovascular Medicine·Amy Lynn DoneenPierre P Leimgruber
May 21, 2020·Lipids in Health and Disease·Nathalie RoyDiane Brisson
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Jan 13, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Eric P Cantey, John T Wilkins
Jan 1, 2016·Current Genetic Medicine Reports·Jacqueline S Dron, Robert A Hegele
Dec 15, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Chan-Won KimSeungho Ryu
Feb 19, 2021·Global Heart·Kavita SinghDorairaj Prabhakaran
Mar 20, 2021·Journal of the American College of Cardiology·Neil J Stone, Donald Lloyd-Jones
Jun 15, 2021·Saudi Journal of Biological Sciences·Rana A AlghamdiNuha A Alkhattabi
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Oct 10, 2021·Nature Reviews. Cardiology·Anurag Mehta, Michael D Shapiro
Sep 16, 2021·The British Journal of Nutrition·Mohsen MazidiIan G Davies

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