Discordance in recovery between altered locomotion and muscle atrophy induced by simulated microgravity in rats

Journal of Motor Behavior
Junichi TajinoHiroshi Kuroki

Abstract

Exposure to a microgravity environment leads to adverse effects in motion and musculoskeletal properties. However, few studies have investigated the recovery of altered locomotion and muscle atrophy simultaneously. The authors investigated altered locomotion in rats submitted to simulated microgravity by hindlimb unloading for 2 weeks. Motion deficits were characterized by hyperextension of the knees and ankle joints and forward-shifted limb motion. Furthermore, these locomotor deficits did not revert to their original form after a 2-week recovery period, although muscle atrophy in the hindlimbs had recovered, implying discordance in recovery between altered locomotion and muscle atrophy, and that other factors such as neural drives might control behavioral adaptations to microgravity.

References

Aug 1, 1992·Journal of Applied Physiology·M A GoldsteinJ P Schroeter
Feb 1, 1992·Journal of Applied Physiology·D S D'AunnoF W Booth
Jul 1, 1990·Journal of Applied Physiology·D A RileyJ W Mellender
Oct 1, 1990·Journal of Applied Physiology·D S D'AunnoF W Booth
Jun 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·S A SistoB Natelson
Jul 1, 1994·The American Journal of Physiology·R E GrindelandI Rudolph
Apr 1, 1996·Canadian Journal of Physiology and Pharmacology·D A McCrea
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·M H Canu, M Falempin
Jan 1, 1997·Brain Research Bulletin·H N SondagW J Oosterveld
Oct 31, 1998·Brain Research. Brain Research Reviews·M F ReschkeV McDonald
Nov 25, 1998·Experimental Brain Research·R RollV Gurfinkel
Dec 5, 1998·European Journal of Applied Physiology and Occupational Physiology·M H Canu, M Falempin
Jan 21, 2000·Journal of Applied Physiology·P E MozdziakE Schultz
Mar 14, 2001·American Journal of Physiology. Cell Physiology·Y OhiraV R Edgerton
Jul 5, 2003·Experimental Brain Research·G E McCallV R Edgerton
Mar 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F KawanoY Ohira
Oct 8, 2004·American Journal of Physiology. Cell Physiology·D A RileyR H Fitts
Mar 12, 2005·The Journal of Physiology·Kerry D WaltonNagi Hatoum
Apr 28, 2005·Journal of Neurotrauma·Anil K ThotaRanu Jung
Jun 7, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Joyce F CarvalhoFernando A M S Pompeu
Nov 7, 2006·Behavioural Brain Research·Artur S P Varejão, Vítor M Filipe
May 24, 2008·Brain Research·Annie A ButlerRichard C Fitzpatrick
Jul 1, 2008·The Journal of Experimental Biology·Carolyn M EngRichard L Lieber
Jan 8, 2011·Journal of Applied Physiology·Yuri P IvanenkoFrancesco Lacquaniti
May 31, 2011·Experimental Neurology·Masaki Ueno, Toshihide Yamashita
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura A MaloneAmy J Bastian
Jul 4, 2012·Experimental Neurology·Cécile LangletMarie-Hélène Canu
Jan 29, 2013·Behavioural Brain Research·Mickael BojadosMarc Jamon
Apr 24, 2013·Behavioural Brain Research·Dave TrinelMarie-Hélène Canu

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BETA
light microscopy

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