Discordance of spatial representation in ensembles of hippocampal place cells

Hippocampus
H TanilaH Eichenbaum

Abstract

The extent to which small ensembles of neighboring hippocampal neurons alter their spatial firing patterns concurrently in response to stimulus manipulations was examined in young adult rats as well as in aged rats with and without memory impairment. Recordings from CA1 and CA3 cells were taken as rats performed a spatial radial-maze task that employed prominent distal visual stimuli attached to dark curtains surrounding the maze and local cues on each maze arm provided by inserts with distinctive visual, tactile, and olfactory stimuli. To test the influence of the different stimulus subsets, the distal and local cues were rotated 90 degrees in opposite directions (a Double Rotation). In response to this manipulation, place fields could maintain a fixed position to room coordinates, rotate with either the local or the distal cues, disappear, or new fields could appear. On average 79% of the cells within an ensemble responded in the same way, but only 37% of all ensembles were fully concordant. Typically discordant ensembles had place fields that rotated with one set of cues, whereas the other fields disappeared or new fields appeared. Ensembles in which the place fields rotated in two opposite directions were less frequent in y...Continue Reading

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Citations

Jun 3, 2004·Neuroscience and Biobehavioral Reviews·Kathryn J JefferySubhojit Chakraborty
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
Jun 12, 2003·Behavioural Brain Research·Christian HölscherHanspeter A Mallot
May 29, 2003·Neuroscience·R D Burwell, D M Hafeman
Dec 24, 2003·Neural Networks : the Official Journal of the International Neural Network Society·S M StringerT P Trappenberg
Jun 14, 2002·Brain Research. Cognitive Brain Research·Sidney I WienerMichaël B Zugaro
Jan 20, 2006·Behavioral Neuroscience·David K Bilkey, Jonathon M Clearwater
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Jan 28, 2005·The European Journal of Neuroscience·Etienne SaveBruno Poucet
Nov 1, 2007·Neural Computation·Mark C Fuhs, David S Touretzky
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·D YoganarasimhaJames J Knierim
May 18, 2006·Reviews in the Neurosciences·Caswell BarryNeil Burgess
Apr 24, 2008·Journal of Computational Neuroscience·Tomas KulviciusFlorentin Wörgötter
Apr 2, 2010·Journal of Neurophysiology·Francesco Savelli, James J Knierim
Aug 26, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amir S BaharMatthew L Shapiro
Feb 22, 2012·Learning & Memory·Isaac A Youngstrom, Ben W Strowbridge
Mar 21, 2007·Hippocampus·Sophie RenaudineauEtienne Save
Jun 29, 2007·Hippocampus·David K Bilkey
Sep 30, 2003·Reviews in the Neurosciences·Christian Hölscher
Oct 2, 2019·Hippocampus·John L KubieAndré A Fenton
Sep 25, 2004·Hippocampus·David S TouretzkyRobert U Muller
Aug 15, 2006·Hippocampus·Janina FerbinteanuMatthew L Shapiro
Aug 10, 2006·Hippocampus·Clifford Kentros
Aug 22, 2006·Hippocampus·Michael I AndersonKathryn J Jeffery
Oct 27, 2017·Nature Neuroscience·Edvard I MoserBruce L McNaughton
May 26, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kathleen M McAvoy, Amar Sahay

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