Abstract
Accurate identification of breast cancer patients most likely to benefit from adjuvant systemic therapies is crucial. Better understanding of differences between methods can lead to an improved ER, PgR, and HER-2 assessment. The purpose of this preplanned translational research is to investigate the correlation of central IHC/FISH assessments with microarray mRNA readouts of ER, PgR, and HER-2 status in the MINDACT trial and to determine if any discordance could be attributed to intratumoral heterogeneity or the DCIS and normal tissue components in the specimens. MINDACT is an international, prospective, randomized, phase III trial investigating the clinical utility of MammaPrint in selecting patients with early breast cancer for adjuvant chemotherapy (n = 6694 patients). Gene-expression data were obtained by TargetPrint; IHC and/or FISH were assessed centrally (n = 5788; 86 %). Macroscopic and microscopic evaluation of centrally submitted FFPE blocks identified 1427 cases for which the very same sample was submitted for gene-expression analysis. TargetPrint ER had a positive agreement of 98 %, and a negative agreement of 95 % with central pathology. Corresponding figures for PgR were 85 and 94 % and for HER-2 72 and 99 %. Agre...Continue Reading
References
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xiao-Jun MaMark G Erlander
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lyndsay HarrisUNKNOWN American Society of Clinical Oncology
May 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sunil S BadveJoseph A Sparano
Nov 6, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul RoepmanMarc J van de Vijver
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederick L BaehnerLaurel A Habel
Sep 15, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenMatthew J Ellis
Oct 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David J DabbsRohit Bhargava
Nov 5, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emiel RutgersFatima Cardoso
Feb 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takayuki IwamotoLajos Pusztai
Feb 4, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·James A KrausRohit Bhargava
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Mar 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G VialeUNKNOWN TRANSBIG Consortium & the MINDACT Investigators
Oct 3, 2015·Breast Cancer Research : BCR·Edith A PerezKarla V Ballman
Apr 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G VialeUNKNOWN TRANSBIG Consortium & the MINDACT Investigators
Citations
Jun 28, 2016·The Breast : Official Journal of the European Society of Mastology·Volker R JacobsPeter Krase
Aug 25, 2016·The New England Journal of Medicine·Fatima CardosoUNKNOWN MINDACT Investigators
Jan 14, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly H AllisonAntonio C Wolff
Jan 14, 2020·Archives of Pathology & Laboratory Medicine·Kimberly H AllisonAntonio C Wolff
Aug 5, 2016·PloS One·Karine Araújo DamascenoGeovanni Dantas Cassali
Sep 9, 2017·PloS One·Alberto Peláez-GarcíaDavid Hardisson
Nov 2, 2017·Oncotarget·Jyotsana SinghalSharad S Singhal
Oct 8, 2016·Oncotarget·Matthias ChristgenDoris Steinemann
Sep 21, 2017·Breast Cancer Research and Treatment·G VialeUNKNOWN MINDACT investigators
Jul 17, 2018·International Journal of Breast Cancer·Ghina B FakhriArafat H Tfayli
Jul 6, 2016·Virchows Archiv : an International Journal of Pathology·Jelle WesselingPino Cusumano
Aug 12, 2020·Cancer·Matthias ChristgenUNKNOWN West German Study Group PlanB Investigators
Jan 28, 2021·Journal of Personalized Medicine·Jiande Wu, Chindo Hicks
Nov 11, 2017·Molecular & Cellular Proteomics : MCP·Vivian DelcourtIsabelle Fournier