Discordant attributes of structural and functional brain connectivity in a two-layer multiplex network

Scientific Reports
S. LimOlaf Sporns

Abstract

Several studies have suggested that functional connectivity (FC) is constrained by the underlying structural connectivity (SC) and mutually correlated. However, not many studies have focused on differences in the network organization of SC and FC, and on how these differences may inform us about their mutual interaction. To explore this issue, we adopt a multi-layer framework, with SC and FC, constructed using Magnetic Resonance Imaging (MRI) data from the Human Connectome Project, forming a two-layer multiplex network. In particular, we examine node strength assortativity within and between the SC and FC layer. We find that, in general, SC is organized assortatively, indicating brain regions are on average connected to other brain regions with similar node strengths. On the other hand, FC shows disassortative mixing. This discrepancy is apparent also among individual resting-state networks within SC and FC. In addition, these patterns show lateralization, with disassortative mixing within FC subnetworks mainly driven from the left hemisphere. We discuss our findings in the context of robustness to structural failure, and we suggest that discordant and lateralized patterns of associativity in SC and FC may provide clues to unde...Continue Reading

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Citations

Sep 20, 2019·PloS One·Douglas R MillerHabibeh Khoshbouei
Jan 11, 2020·Frontiers in Human Neuroscience·Dionissios T HristopulosNaznin Virji-Babul
Mar 12, 2020·Trends in Cognitive Sciences·Laura E SuárezBratislav Misic
Oct 26, 2021·Frontiers in Human Neuroscience·Chengyuan WuHarith Akram

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Software Mentioned

R
Matlab
Brain Connectivity Toolbox
FreeSurfer
FSL
EPSGO

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