Discordant clinical presentation and outcome in infant twins sharing a common clonal leukaemia

British Journal of Haematology
M CampbellM Greaves

Abstract

We report the different presentation features and clinical outcome between two identical infant twins with acute lymphoblastic leukaemia with a shared clonal disease and MLL gene rearrangement. One twin relapsed and died, but the other is in complete remission > 4 years after diagnosis. These data, and similar observations on other twin infants with leukaemia, suggest that despite a common clonal in utero, post-natally these leukaemias can evolve independently, at different rates, in the twinned individuals, and that the usually fatal leukaemia associated with t(4;11) MLL gene rearrangement can be effectively treated when the leukaemic burden is small.

Citations

Jun 28, 2006·Acta Paediatrica. Supplement·Matteo LucianiGiulio De Rossi
Jun 10, 2003·Journal of Pediatric Hematology/oncology·Jakub Tolar, Joseph P Neglia
Apr 9, 2011·Leukemia Research·Rishi S KotechaCatherine H Cole
Feb 1, 2006·British Journal of Haematology·Ronald W StamRob Pieters
Apr 6, 2004·Leukemia & Lymphoma·Jeffrey W Taub, Yubin Ge
Jun 7, 2003·Blood·Mel F GreavesAnthony M Ford
Dec 31, 2020·Pediatric Reports·Golamreza BahoushRoxana Kariminejad

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