Discordant CSF/plasma HIV-1 RNA in individuals on virologically suppressive antiretroviral therapy in Western India

Medicine
Ameet N DravidRustom S Wadia

Abstract

Aim of this study was to estimate the prevalence of cerebrospinal fluid (CSF)/Plasma HIV-1 RNA discordance in virologically suppressed individuals presenting with incident neurologic symptoms.In this retrospective cohort study conducted between March 1, 2009, and March 1, 2017, HIV-1 infected adults exposed to atleast 12 months of antiretroviral therapy (ART) and having plasma viral load (VL) <1000 copies/mL (virologically suppressed) were included. Among these, individuals presenting with neurologic symptoms during follow-up were assessed for CSF/Plasma HIV-1 RNA discordance by measuring HIV-1 RNA in collected plasma and CSF samples. CSF/plasma HIV-1 RNA discordance was defined as either detectable CSF HIV-1 RNA (VL > 20 copies/mL) with an undetectable plasma RNA (complete viral suppression, VL ≤20 copies/mL) or CSF HIV-1 RNA ≥ 0.5 log10 higher than plasma RNA when plasma VL was between 20 and 1000 copies/mL (low-level viremia, LLV).Out of 1584 virologically suppressed patients, 71 (4.4%) presented with incident neurologic symptoms. Twenty out of 71 (28.2%) patients were diagnosed with CSF/Plasma HIV-1 discordance. Median plasma and CSF VL in patients with discordance was 120 [interquartile range (IQR): <20 to 332.5] and 4250 ...Continue Reading

References

Feb 7, 1998·The Journal of Clinical Investigation·R B KimG R Wilkinson
Jul 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G TambussiA Lazzarin
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen A Wendel, Justin C McArthur
Nov 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea AntinoriStephen C Piscitelli
Dec 4, 2008·AIDS·Brookie M BestUNKNOWN CHARTER Group
May 9, 2009·AIDS·Christina M MarraUNKNOWN AIDS Clinical Trials Group 736 Study Team
Jan 27, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ana CanestriChristine Katlama
Mar 31, 2010·The Journal of Infectious Diseases·Nicola E MackieAnna-Maria Geretti
Sep 14, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M VissersP P Koopmans
Nov 6, 2010·The Journal of Infectious Diseases·Arvid EdénMagnus Gisslén
Feb 23, 2011·Neurology·L GarveyUNKNOWN UK Collaborative HIV Cohort (CHIC) study
Apr 21, 2011·AIDS Research and Human Retroviruses·María del Palacio TamaritJosé L Casado
Jun 11, 2011·The Journal of Infection·Isaac I BogochNagagopal Venna
Oct 15, 2011·International Journal of STD & AIDS·R BinghamJ Green
Dec 14, 2011·Current Opinion in Infectious Diseases·Tomas Doyle, Anna Maria Geretti
May 4, 2012·The Journal of Infectious Diseases·Victor ValcourUNKNOWN RV254/SEARCH 010 Study Group
Jan 25, 2013·Antiviral Therapy·Marieke BierhoffReinier W Ten Kate
Jun 6, 2013·Journal of Neurovirology·Michael N KhouryIgor J Koralnik
Aug 16, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claudie LapriseHelen Trottier
Dec 20, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ronald J EllisJ Allen McCutchan
Aug 27, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Davide MangioniAlessandra Bandera
Oct 5, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea CalcagnoStefano Bonora
Oct 16, 2014·Lancet Neurology·Sam NightingaleTom Solomon
Apr 11, 2015·Current HIV/AIDS Reports·Francesca FerrettiRichard W Price
May 20, 2016·Journal of Neurovirology·Sam NightingaleSaye Khoo
Nov 4, 2016·Medical Microbiology and Immunology·Maximilian DonathUNKNOWN for Frankfurt HIV Cohort Study
Mar 23, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shibani S MukerjiDana Gabuzda

❮ Previous
Next ❯

Citations

Mar 10, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Hemil GonzalezJennillee Wallace
Apr 26, 2020·Current Opinion in Infectious Diseases·Kiran T Thakur
Dec 4, 2019·AIDS·Andrea MastrangeloPaola Cinque
Sep 3, 2020·Current HIV/AIDS Reports·Francesca FerrettiPaola Cinque
Feb 26, 2019·Oxford Medical Case Reports·Kenneth SsebambuliddeAndrea Calcagno

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

STATA

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.