PMID: 15222693Jun 30, 2004Paper

Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

Multiple Sclerosis : Clinical and Laboratory Research
Kathleen M HealeyRichard A Nash

Abstract

This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.

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Citations

Nov 19, 2010·Expert Review of Hematology·Claudio AnnaloroGiorgio Lambertenghi Deliliers
Sep 30, 2009·Acta Neurologica Scandinavica·C Rogojan, J L Frederiksen

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