Discordant orthostatic reflex renin-angiotensin and sympathoneural responses in premenopausal exercising-hypoestrogenic women

Hypertension
Emma O'DonnellPaula J Harvey

Abstract

Our prior observations in normotensive postmenopausal women stimulated the hypotheses that compared with eumenorrheic women, active hypoestrogenic premenopausal women with functional hypothalamic amenorrhea would demonstrate attenuated reflex renin-angiotensin-aldosterone system responses to an orthostatic challenge, whereas to defend blood pressure reflex increases in muscle, sympathetic nerve activity would be augmented. To test these hypotheses, we assessed, in recreationally active women, 12 with amenorrhea (ExFHA; aged 25 ± 1 years; body mass index 20.7 ± 0.7 kg/m(2); mean ± SEM) and 17 with eumenorrhea (ExOv; 24 ± 1 years; 20.9 ± 0.5 kg/m(2)), blood pressure, heart rate, plasma renin, angiotensin II, aldosterone, and muscle sympathetic nerve activity at supine rest and during graded lower body negative pressure (-10, -20, and -40 mm Hg). At baseline, heart rate and systolic blood pressure were lower (P<0.05) in ExFHA (47 ± 2 beats/min and 94 ± 2 mm Hg) compared with ExOv (56 ± 2 beats/min and 105 ± 2 mm Hg), but muscle sympathetic nerve activity and renin-angiotensin-aldosterone system constituents were similar (P>0.05). In response to graded lower body negative pressure, heart rate increased (P<0.05) and systolic blood p...Continue Reading

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Citations

Jul 15, 2015·Experimental Physiology·Michael J JoynerNisha Charkoudian
May 19, 2018·British Journal of Sports Medicine·Margo MountjoyRichard Budgett
Jun 4, 2018·British Journal of Sports Medicine·Kathryn E AckermanAllyson L Parziale
May 18, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Margo MountjoyRichard Budgett
Oct 9, 2019·Scandinavian Journal of Medicine & Science in Sports·Therese Fostervold MathisenJorunn Sundgot-Borgen
Mar 3, 2020·Scandinavian Journal of Medicine & Science in Sports·Emma O'DonnellPaula J Harvey
Oct 10, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Massimo NardonePhilip J Millar
Sep 14, 2021·Sports Medicine·Bryan Holtzman, Kathryn E Ackerman

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