Discordant pathological diagnosis of non-alcoholic fatty liver disease: A prospective multicenter study

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
Takuya KuwashiroYuichiro Eguchi

Abstract

Liver biopsy has been the standard procedure for diagnosing and evaluating the severity of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH); however, interobserver discordance remains a critical issue in its pathological diagnosis. We examined the concordance rates of pathological scoring and diagnosis between pathologists at individual institutions (local diagnosis) and two central pathologists specialized in liver pathology (central diagnosis). A total of 150 patients with NAFLD underwent prospective liver biopsies. NAFLD activity score (NAS) and fibrosis stage were evaluated, and NASH was determined according to Matteoni's classification. NAS, scores for all NAS components, and fibrosis stage were diagnosed at a lower degree by central compared with local diagnosis. NASH was diagnosed in 34% of the patients according to central pathologists compared with 54% according to local pathologists (P < 0.001). The concordance rates for NAS, steatosis, inflammation, ballooning, fibrosis, and NASH diagnosis were 26.7, 62.7, 51.3, 48.7, 43.3, and 50.7%, respectively. The correlation coefficient between local and central diagnoses was the lowest for the scoring of ballooning (ρ = 0.218). Concordance rat...Continue Reading

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Citations

Nov 3, 2020·Journal of Medical Ultrasonics·Masayoshi KageHirohisa Yano
Nov 18, 2020·Diagnostics·Satoshi OedaHirokazu Takahashi
Jun 30, 2021·Journal of Diabetes and Its Complications·Alshaima AlhinaiGiada Sebastiani
Sep 9, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nobuharu TamakiRohit Loomba

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS Statistics

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