Discordant perspectives of rheumatologists and patients on COBRA combination therapy in rheumatoid arthritis

Rheumatology
L H D van TuylMaarten Boers

Abstract

The COBRA therapy (combination therapy in early rheumatoid arthritis) has proven to be an effective treatment for early RA, but is rarely prescribed. A survey showed reluctance of Dutch reumatologists to apply COBRA therapy in early RA. The present qualitative study was carried out to further explore the reservation of Dutch rheumatologists towards prescribing COBRA therapy and include patients' view on (components of) COBRA therapy. Two focus group discussions were undertaken for rheumatologists (n(1) = 8, n(2) = 7) and two for patients (n(1) = 4, n(2) = 8). In addition, in-depth interviews were conducted with 11 rheumatologists and 1 patient. These were taped and transcribed. Two independent researchers identified themes and these were discussed with three other researchers. Rheumatologists were positive concerning effectiveness of COBRA therapy, but highly concerned about their patients' possible negative reaction to the large amount of pills to be prescribed. In addition, rheumatologists perceived lack of time explaining and prescribing COBRA therapy and felt uncomfortable prescribing high doses of prednisolone. Patients were positive about an aggressive combination therapy such as COBRA, and they had no qualms taking many ...Continue Reading

References

Mar 21, 2007·Annals of Internal Medicine·Yvonne P M Goekoop-RuitermanBen A C Dijkmans
Mar 30, 2007·Annals of the Rheumatic Diseases·Lilian H D van TuylMaarten Boers

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Citations

Oct 8, 2011·Zeitschrift für Rheumatologie·E Gromnica-Ihle, M Rink
May 19, 2011·Rheumatology·Zoe Paskins, Andrew B Hassell
Jun 11, 2015·Expert Opinion on Pharmacotherapy·Diederik De CockRené Westhovens
Mar 25, 2015·Expert Opinion on Drug Safety·Linda A RaschWillem F Lems
Jan 24, 2012·Best Practice & Research. Clinical Rheumatology·Per QvistMorten A Karsdal
Dec 17, 2014·Arthritis Care & Research·Ingrid NotaMart A F J van de Laar
Feb 25, 2014·Scandinavian Journal of Rheumatology·S MeyfroidtP Verschueren
Dec 3, 2014·Scandinavian Journal of Rheumatology·M IudiciG Valentini
Dec 9, 2014·Patient Education and Counseling·Sabrina MeyfroidtPatrick Verschueren
Jun 3, 2009·The Journal of Rheumatology·Lilian H D van TuylMaarten Boers
Aug 3, 2011·The Journal of Rheumatology·Lilian H D van TuylMaarten Boers

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