Discovering Associations of Adverse Events with Pharmacotherapy in Patients with Non-Small Cell Lung Cancer Using Modified Apriori Algorithm

BioMed Research International
Wei ChenGuo-Hui Li

Abstract

To explore the associations between adverse events and pharmacotherapy in patients with non-small cell lung cancer. 16,527 patients with non-small cell lung cancer admitted to the Cancer Hospital, Chinese Academy of Medical Sciences, between January 1, 2010, and December 31, 2016, were included in the study. Their medication and laboratory examinations data were extracted from the medical records. Common Terminology Criteria for Adverse Events Version 4.03 were utilized for adverse events reporting. A new association algorithm was developed based on Apriori algorithm and used to investigate the associations between drugs and adverse events. In addition, a statistical comparison was conducted to compare the modified Apriori algorithm with the conventional Apriori algorithm. Different types and levels of adverse events were identified from the abnormal laboratory findings. The three most common adverse events were hypocalcemia, elevated creatine phosphokinase, and hypertriglyceridemia. In addition, using the modified Apriori algorithm, 380 association rules were found between adverse events and chemotherapy. Moreover, the statistical comparison of the two methods demonstrated that the modified Apriori algorithm was more advantage...Continue Reading

References

Aug 4, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·David S EttingerUNKNOWN NCCN Non-Small Cell Lung Cancer Panel Members
Dec 12, 2013·Tumori·Alberto Ruano-RavinaJuan Miguel Barros-Dios
Jun 24, 2014·TheScientificWorldJournal·Sajid MahmoodAziz Guergachi
Oct 31, 2014·Oncology Nursing Forum·Denise Soltow HersheyMarilyn Hammer
Mar 24, 2015·Molecular and Clinical Oncology·Yuichi SakamoriMichiaki Mishima
Nov 8, 2015·Advanced Drug Delivery Reviews·Quanyin HuZhen Gu
Apr 12, 2016·SpringerPlus·Seyed Abbas MahmoodiSeyed Mostafa Mahmoudi
Dec 19, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nasser H HannaUNKNOWN LUME-Lung 2 Study group
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May 10, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Pedro Giavina-BianchiAleena Banerji

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BETA
pharmacotherapy

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SQL server
MATLAB

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