Discovering implicit protein-protein interactions in the cell cycle using bioinformatics approaches

Journal of Biomedical Science
Mathew PalakalDavid L Stocum

Abstract

The cell division control protein (Cdc2) kinase is a catalytic subunit of a protein kinase complex, called the M phase promoting factor, which induces entry into mitosis and is universal among eukaryotes. This protein is believed to play a major role in cell division and control. The lives of biological cells are controlled by proteins interacting in metabolic and signaling pathways, in complexes that replicate genes and regulate gene activity, and in the assembly of the cytoskeletal infrastructure. Our knowledge of protein-protein (P-P) interactions has been accumulated from biochemical and genetic experiments, including the widely used yeast two-hybrid test. In this paper we examine if P-P interactions in regenerating tissues and cells of the anuran Xenopus laevis can be discovered from biomedical literature using computational and literature mining techniques. Using literature mining techniques, we have identified a set of implicitly interacting proteins in regenerating tissues and cells of Xenopus laevis that may interact with Cdc2 to control cell division. Genome sequence based bioinformatics tools were then applied to validate a set of proteins that appear to interact with the Cdc2 protein. Pathway analysis of these prote...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Dec 1, 1994·Current Opinion in Cell Biology·T R Coleman, W G Dunphy
Mar 17, 1994·Nature·W R MoyleX Wang
Feb 16, 1996·The Journal of Biological Chemistry·R E van KesterenW P Geraerts
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·M Jucovic, R W Hartley
Dec 1, 1996·Current Opinion in Cell Biology·D J Lew, S Kornbluth
Aug 29, 1997·Journal of Molecular Biology·F PazosA Valencia
Jan 15, 1999·Immunogenetics·A L Hughes, M Yeager
Jun 22, 2000·Journal of Molecular Biology·C S GohF E Cohen
Oct 13, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·M NakanishiM Sasaki
Jan 11, 2000·Nucleic Acids Research·G D BaderC W Hogue
Apr 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ItoY Sakaki
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·E A Nigg
Nov 15, 2001·Protein Engineering·F Pazos, A Valencia
Jan 10, 2002·Genome Research·Ronald JansenMark Gerstein
Mar 27, 2002·Genes & Development·Anuj KumarMichael Snyder
Apr 27, 2002·Science·Hunter B FraserMarcus W Feldman
Sep 10, 2002·Developmental Biology·Walter Leise, Paul R Mueller
Oct 12, 2002·Bioinformatics·Mathew PalakalSantosh Mishra
Jan 10, 2003·Nucleic Acids Research·Brigitte BoeckmannMichel Schneider
Jan 14, 2003·Nature Cell Biology·Mark JackmanJonathon Pines
Mar 5, 2003·Journal of Molecular Biology·Arun K Ramani, Edward M Marcotte
Apr 25, 2003·Nucleic Acids Research·Dongbo BuRunsheng Chen
Aug 4, 2004·Journal of Bioinformatics and Computational Biology·Mathew PalakalSimon Rhodes
Aug 18, 2004·Nature Cell Biology·Alwin KrämerJiri Lukas
Dec 14, 2004·Journal of Biomedical Science·Vijay NarayanasamyDavid A Potter
Sep 2, 2005·Nature·Steve E CalvanoUNKNOWN Inflamm and Host Response to Injury Large Scale Collab. Res. Program
Nov 4, 2006·Journal of Biomedical Science·Mathew PalakalShielly Hartanto

❮ Previous
Next ❯

Citations

May 21, 2015·Journal of Biomedical Semantics·Peggy CellierJean-Luc Manguin
Feb 20, 2013·Bioprocess and Biosystems Engineering·Valentina VologniBooki Min
May 12, 2011·Annals of Botany·Dennis Francis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.