Discovering less toxic ionic liquids by using the Microtox® toxicity test

Ecotoxicology and Environmental Safety
F J Hernández-FernándezJ Quesada-Medina

Abstract

New Microtox® toxicity data of 16 ionic liquids of different cationic and anionic composition were determined. The ionic liquids 1-butyl-1-methylpyrrolidinium trifluoromethanesulfonate, [BMPyr(+)][TFO(-)], 1-butyl-1-methylpyrrolidinium chloride, [BMPyr(+)][Cl(-)], hydroxypropylmethylimidazolium fluoroacetate, [HOPMIM(+)][FCH2COO(-)], and hydroxypropylmethylimidazolium glycolate [HOPMIM(+)][glycolate(-)] were found to be less toxic than conventional organic solvent such as chloroform or toluene, accoding the Microtox® toxicity assays. The toxicity of pyrrolidinium cation was lower than the imidazolium and pyridinium ones. It was found that the inclusion of an hydroxyl group in the alkyl chain length of the cation also reduce the toxicity of the ionic liquid. To sum up, the Microtox® toxicity assays can be used as screening tool to easily determined the toxicity of a wide range of ionic liquids and the toxicity data obtained could allow the obtention of structure-toxicity relationships to design less toxic ionic liquids.

References

Jan 1, 2005·Human & Experimental Toxicology·P StepnowskiE Laczyńska
Feb 3, 2005·Environmental Toxicology and Chemistry·Randall J BernotGary A Lamberti
Oct 13, 2006·Ecotoxicology and Environmental Safety·Johannes RankeBernd Jastorff
Oct 19, 2007·Environmental Toxicology and Chemistry·Chiara SamorìEmilio Tagliavini
Dec 8, 2007·Journal of Hazardous Materials·A RomeroA Rodríguez
Apr 4, 2009·Ecotoxicology and Environmental Safety·Chung Yuan ChenChao Fen Yang
Jul 21, 2009·Bioorganic & Medicinal Chemistry Letters·Vineet Kumar, Sanjay V Malhotra
Oct 27, 2009·Water Research·Thi Phuong Thuy PhamYeoung-Sang Yun
Jun 1, 2010·Human & Experimental Toxicology·Raquel Fm Frade, Carlos Am Afonso
Mar 16, 2012·Journal of Hazardous Materials·Sylvie ViboudDominique Fontvieille
Mar 16, 2012·Ecotoxicology and Environmental Safety·Paula C A G PintoM Lúcia M F S Saraiva
Aug 6, 2013·Journal of Hazardous Materials·Brezana PericStefan Stolte

❮ Previous
Next ❯

Citations

Feb 20, 2016·Journal of Hazardous Materials·Susana P F CostaM Lúcia M F S Saraiva
Jan 26, 2016·Chemosphere·Yunchang FanChengcheng Pan
Jan 24, 2016·International Journal of Biological Macromolecules·Xing DongShaofeng Hua
Oct 8, 2015·Environmental Science & Technology·Meseret AmdeLong Pang
Sep 25, 2016·Environmental Science and Pollution Research International·Natalia SzczepańskaBłażej Kudłak
Apr 11, 2017·ChemSusChem·Susana P F CostaM Lúcia M F S Saraiva
Mar 30, 2018·Physical Chemistry Chemical Physics : PCCP·Cesar HerreraSantiago Aparicio
Dec 22, 2019·Biotechnology Journal·Magaret SivapragasamMasahiro Goto
Jun 5, 2017·Environmental Monitoring and Assessment·Natalia SzczepańskaJacek Namieśnik
Nov 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Błażej KudłakJacek Namieśnik
Sep 8, 2019·Ecotoxicology and Environmental Safety·Juan J ParajóSónia P M Ventura
May 12, 2021·The Science of the Total Environment·Chul-Woong ChoYeoung-Sang Yun
Aug 28, 2020·Ecotoxicology and Environmental Safety·Tian LanQiang Wang
Jun 3, 2021·International Journal of Molecular Sciences·Ana R P GonçalvesCarla S G P Queirós
Oct 5, 2015·ACS Sustainable Chemistry & Engineering·Tânia E SintraJoão A P Coutinho
Aug 29, 2021·Journal of Applied Toxicology : JAT·Rachel P FrawleyKristen Ryan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Physical Chemistry. B
Ana M FernandesLuís M N B F Santos
Experientia. Supplementum
L Vrbovský
Journal of Chemical Education
G W Gribble
© 2022 Meta ULC. All rights reserved