Discovering potential drug-targets for personalized treatment of autoimmune disorders - what we learn from epidermolysis bullosa acquisita

Expert Opinion on Therapeutic Targets
Mareike WitteKatja Bieber

Abstract

Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune bullous dermatosis (AIBD). Treatment of EBA is challenging and mostly relies on systemic immunosuppression. During the last decade, intensive research led to the identification of new potential therapeutic targets that interfere in different phases of disease progression. Therapeutic interventions acting upon these candidate drug targets in animal models of EBA, such as cytokine-modulating biologics and small molecules, have validated them as potential new therapeutic strategies for EBA patients. In this paper, we review the current treatments for EBA, describe the pathogenesis of the disease, and finally specify new drug candidates for the development of a more specific therapy with minimized side-effects for EBA and potentially other autoimmune diseases. We currently understand EBA as a disease that evolves from the interplay of many different signaling pathways. These signaling pathways, which are described in this review, provide new targets for EBA treatment. The ultimate goal of this research field is the development of specific, pathogenesis-based therapeutic strategies. Through identification of up- or downregulated pathways that dominate disease progression ...Continue Reading

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Citations

Dec 12, 2017·Frontiers in Immunology·Katja BieberRalf J Ludwig
Feb 12, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jie PengPeiquan Zhao
Jan 29, 2019·Frontiers in Medicine·Hiroshi KogaKatja Bieber
Aug 27, 2019·Therapeutic Advances in Ophthalmology·Tanima Bose
Nov 20, 2018·Frontiers in Medicine·Mareike WitteEnno Schmidt
May 26, 2020·The Journal of Investigative Dermatology·Pia StüsselKatja Bieber

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