Discovery and characterisation of a new insect-specific bunyavirus from Culex mosquitoes captured in northern Australia

Virology
Jody Hobson-PetersR A Hall

Abstract

Insect-specific viruses belonging to significant arboviral families have recently been discovered. These viruses appear to be maintained within the insect population without the requirement for replication in a vertebrate host. Mosquitoes collected from Badu Island in the Torres Strait in 2003 were analysed for insect-specific viruses. A novel bunyavirus was isolated in high prevalence from Culex spp. The new virus, provisionally called Badu virus (BADUV), replicated in mosquito cells of both Culex and Aedes origin, but failed to replicate in vertebrate cells. Genomic sequencing revealed that the virus was distinct from sequenced bunyavirus isolates reported to date, but phylogenetically clustered most closely with recently discovered mosquito-borne, insect-specific bunyaviruses in the newly proposed Goukovirus genus. The detection of a functional furin cleavage motif upstream of the two glycoproteins in the M segment-encoded polyprotein suggests that BADUV may employ a unique strategy to process the virion glycoproteins.

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Citations

Mar 14, 2018·The Journal of General Virology·Natalie A ProwRoy A Hall
Jan 18, 2017·Evolutionary Bioinformatics Online·Roy A HallJody Hobson-Peters
Mar 9, 2018·Critical Reviews in Microbiology·Yeping SunWenjun Liu
Sep 20, 2019·Viruses·Eric AgboliEsther Schnettler
Dec 13, 2019·Science Translational Medicine·Jody Hobson-PetersRoy A Hall
Sep 15, 2021·Vector Borne and Zoonotic Diseases·Ashok MunivenkatappaPatil OmPrakash

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