Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation.

The Journal of Biological Chemistry
Robert P T SomervilleSuneel S Apte

Abstract

We describe the discovery and characterization of ADAMTS10, a novel metalloprotease encoded by a locus on human chromosome 19 and mouse chromosome 17. ADAMTS10 has the typical modular organization of the ADAMTS family, with five thrombospondin type 1 repeats and a cysteine-rich PLAC (protease and lacunin) domain at the carboxyl terminus. Its domain organization and primary structure is similar to a novel long form of ADAMTS6. In contrast to many ADAMTS proteases, ADAMTS10 is widely expressed in adult tissues and throughout mouse embryo development. In situ hybridization analysis showed widespread expression of Adamts10 in the mouse embryo until 12.5 days of gestation, after which it is then expressed in a more restricted fashion, with especially strong expression in developing lung, bone, and craniofacial region. Mesenchymal, not epithelial, expression in the developing lung, kidney, gonad, salivary gland, and gastrointestinal tract is a consistent feature of Adamts10 regulation. N-terminal sequencing and treatment with decanoyl-Arg-Val-Lys-Arg-chloromethylketone indicate that the ADAMTS10 zymogen is processed by a subtilisin-like proprotein convertase at two sites (Arg64/Gly and Arg233/Ser). The widespread expression of ADAMTS...Continue Reading

References

May 1, 1990·The Journal of Membrane Biology·G von Heijne
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Apr 25, 1997·The Journal of Biological Chemistry·T BrinkmannK Kleesiek
Aug 7, 1999·The Journal of Biological Chemistry·I AbbaszadeT C Burn
Feb 5, 2000·Journal of Molecular Endocrinology·F BergeronR Day
Apr 7, 2000·The Journal of Biological Chemistry·M D TortorellaE Arner
Aug 17, 2000·The Journal of Biological Chemistry·J C Rodriguez-ManzanequeM L Iruela-Arispe
Jun 16, 2001·The Journal of Biological Chemistry·R J FernandesS S Apte
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Dec 14, 2001·The Journal of Biological Chemistry·Alain ColigeBetty V Nusgens
Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Farrah Kheradmand, Zena Werb
Jan 18, 2002·The Journal of Biological Chemistry·Gui GaoJohn D Sandy
Jan 24, 2002·The Journal of Biological Chemistry·Satoshi HirohataSuneel S Apte
Jun 11, 2002·Biochemical and Biophysical Research Communications·Juan Carlos Rodríguez-ManzanequeM Luisa Iruela-Arispe
Jan 7, 2003·The Journal of Biological Chemistry·Robert P T SomervilleSuneel S Apte
Mar 21, 2003·The Journal of Biological Chemistry·Wei-Man WangDaniel S Greenspan
Jun 10, 2003·Nature Structural Biology·Stefan HenrichManuel E Than
Jun 13, 2003·Genome Biology·Robert P T SomervilleSuneel S Apte
Jun 20, 2003·Annals of the New York Academy of Sciences·M Luisa Iruela-ArispeAlfonso Luque
Dec 10, 2003·The Journal of Biological Chemistry·Masahide KashiwagiHideaki Nagase
Jan 13, 2004·The Journal of Biological Chemistry·Micky D TortorellaAnne-Marie Malfait
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·Suneel S Apte
Jun 12, 2004·The Journal of Biological Chemistry·Robert P T SomervilleSuneel S Apte

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Citations

May 9, 2009·Human Molecular Genetics·Bina JoeClaude Bouchard
Mar 31, 2006·Journal of Medical Genetics·P N RobinsonM Godfrey
Nov 5, 2010·Molecular Cancer Research : MCR·Xiaomu WeiYardena Samuels
Feb 21, 2013·Investigative Ophthalmology & Visual Science·John KuchteyRachel W Kuchtey
Feb 14, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·John Kuchtey, Rachel W Kuchtey
Sep 19, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·İrem Eda GökdemirKadir Demircan
Nov 11, 2008·The International Journal of Biochemistry & Cell Biology·Jean-Michel LongpréRichard Leduc
Aug 19, 2015·The Veterinary Clinics of North America. Small Animal Practice·András M Komáromy, Simon M Petersen-Jones
Jul 22, 2008·The FEBS Journal·Shinji Ihara, Kiyoji Nishiwaki
Apr 29, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yi SunZuli Yang
Aug 19, 2016·Scientific Reports·Go-Woon KimKyung-Ok Cho
Oct 26, 2016·Scientific Reports·Stuart A CainCay M Kielty
Nov 7, 2016·Molecular and Cellular Endocrinology·Zhongyi ShenShereen Ezzat
Jul 31, 2018·Human Molecular Genetics·Ewa J MularczykClair Baldock
Mar 16, 2006·The Journal of Biological Chemistry·Bon-Hun KooSuneel S Apte
Nov 24, 2004·The Biochemical Journal·Sarah PorterDylan R Edwards
Apr 16, 2020·Critical Reviews in Biochemistry and Molecular Biology·Lise BoonGhislain Opdenakker
Apr 4, 2007·The Journal of Biological Chemistry·Bon-Hun KooSuneel S Apte
Oct 31, 2009·The Journal of Biological Chemistry·Bon-Hun Koo, Suneel S Apte
Oct 6, 2018·Biology Open·Tomoko MatsuzakiMakoto Noda
Sep 4, 2020·Annals of the New York Academy of Sciences·Sarah StanleyDirk Hubmacher
Jul 17, 2021·Frontiers in Molecular Biosciences·Keron W J RoseDirk Hubmacher
Jun 9, 2005·Gene Expression Patterns : GEP·Katherine A JungersSuneel S Apte
Aug 24, 2021·Investigative Ophthalmology & Visual Science·Hang-Jing WuJohn Kuchtey
Aug 2, 2008·Archives of Biochemistry and Biophysics·Anne-Marie MalfaitMicky D Tortorella

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