Discovery and characterization of ACE2 - a 20-year journey of surprises from vasopeptidase to COVID-19.

Clinical Science
Nigel M HooperAnthony J Turner


Angiotensin-converting enzyme (ACE) is a zinc membrane metallopeptidase that plays a key role in regulating vasoactive peptide levels and hence cardiovascular activity through its conversion of angiotensin I (Ang I) to Ang II and its metabolism of bradykinin. The discovery of its homologue, ACE2, 20 years ago has led to intensive comparisons of these two enzymes revealing surprising structural, catalytic and functional distinctions between them. ACE2 plays multiple roles not only as a vasopeptidase but also as a regulator of amino acid transport and serendipitously as a viral receptor, mediating the cellular entry of the coronaviruses causing severe acute respiratory syndrome (SARS) and, very recently, COVID-19. Catalytically, ACE2 functions as a monocarboxypeptidase principally converting the vasoconstrictor angiotensin II to the vasodilatory peptide Ang-(1-7) thereby counterbalancing the action of ACE on the renin-angiotensin system (RAS) and providing a cardioprotective role. Unlike ACE, ACE2 does not metabolise bradykinin nor is it inhibited by classical ACE inhibitors. However, it does convert a number of other regulatory peptides in vitro and in vivo. Interest in ACE2 biology and its potential as a possible therapeutic ta...Continue Reading


Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F SoubrierP Corvol
Oct 31, 1994·FEBS Letters·N M Hooper
Jan 15, 1997·The Biochemical Journal·N M HooperA J Turner
Apr 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A J Turner, K Tanzawa
Jan 30, 2002·The Journal of Biological Chemistry·Chad VickersPeter Tummino
Apr 5, 2002·Trends in Pharmacological Sciences·Anthony J Turner, Nigel M Hooper
May 25, 2002·Canadian Journal of Physiology and Pharmacology·Anthony J TurnerNigel M Hooper
Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Oct 3, 2002·Journal of the American Chemical Society·Natalie A DalesMichael A Patane
Jan 24, 2003·Nature·Ramanathan NateshK Ravi Acharya
Feb 28, 2003·The Journal of Biological Chemistry·Lili HuangRobert C Ladner
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Mar 1, 1956·The Journal of Experimental Medicine·L T SKEGGSN P SHUMWAY
Feb 3, 2004·The Journal of Biological Chemistry·Paul TowlerMichael W Pantoliano
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Heike HofmannStefan Pöhlmann
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Dec 7, 2005·Cell Metabolism·Kenji FukuiKazuya Yamagata
Mar 28, 2006·Journal of Chemical Information and Modeling·Monika RellaRichard M Jackson
Sep 21, 2006·American Journal of Physiology. Renal Physiology·Sandra M MalakauskasThu H Le
Dec 15, 2006·Nature·Ursula DanilczykJosef M Penninger
Apr 28, 2007·The Journal of Pathology·I HammingH van Goor
Mar 8, 2008·Journal of Medicinal Chemistry·Andreas MoresVincent Dive

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Dec 12, 2020·Clinical Science·Michael BaderNatalia Alenina
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