Discovery and characterization of chromatin states for systematic annotation of the human genome

Nature Biotechnology
Jason Ernst, Manolis Kellis

Abstract

A plethora of epigenetic modifications have been described in the human genome and shown to play diverse roles in gene regulation, cellular differentiation and the onset of disease. Although individual modifications have been linked to the activity levels of various genetic functional elements, their combinatorial patterns are still unresolved and their potential for systematic de novo genome annotation remains untapped. Here, we use a multivariate Hidden Markov Model to reveal 'chromatin states' in human T cells, based on recurrent and spatially coherent combinations of chromatin marks. We define 51 distinct chromatin states, including promoter-associated, transcription-associated, active intergenic, large-scale repressed and repeat-associated states. Each chromatin state shows specific enrichments in functional annotations, sequence motifs and specific experimentally observed characteristics, suggesting distinct biological roles. This approach provides a complementary functional annotation of the human genome that reveals the genome-wide locations of diverse classes of epigenetic function.

References

Jan 19, 2000·Nature·B D Strahl, C David Allis
Jun 5, 2002·Genome Research·William KentDavid Haussler
Jan 16, 2003·Cell·Stuart L Schreiber, Bradley E Bernstein
Apr 18, 2003·Human Molecular Genetics·Terrence S Furey, David Haussler
Dec 19, 2003·Nucleic Acids Research·Dennis A BensonDavid L Wheeler
Apr 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
Jul 19, 2005·Genome Research·Adam SiepelDavid Haussler
Apr 7, 2006·BMC Bioinformatics·Jason Ernst, Ziv Bar-Joseph
Apr 29, 2006·Nature Genetics·Piero CarninciYoshihide Hayashizaki
Feb 27, 2007·Cell·Bradley E BernsteinEric S Lander
Feb 27, 2007·Cell·Tony Kouzarides
Mar 27, 2007·Bioinformatics·Nathan DayWilliam Stafford Noble
Jun 5, 2007·PLoS Genetics·Henriette O'GeenPeggy J Farnham
Jun 15, 2007·Genome Research·Robert E ThurmanJohn A Stamatoyannopoulos
Oct 19, 2007·Nature·International HapMap ConsortiumJohn Stewart
Nov 7, 2007·Genome Research·Webb MillerW James Kent
Nov 9, 2007·Genome Research·Pouya KheradpourManolis Kellis
Dec 19, 2007·Nucleic Acids Research·D KarolchikWilliam Kent
Mar 11, 2008·Cell·Dustin E SchonesKeji Zhao
Nov 11, 2008·Genome Research·Xiaowo WangMichael Q Zhang
Dec 20, 2008·BMC Bioinformatics·Kyoung-Jae WonWei Wang
Jan 16, 2009·PLoS Biology·Bernd SchuettengruberGiacomo Cavalli
Feb 3, 2009·Nature Genetics·Paulina Kolasinska-ZwierzJulie Ahringer
Feb 10, 2009·Nature Genetics·Daníel F GudbjartssonKari Stefansson
May 8, 2009·Genome Research·Ruiqiang LiJun Wang
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
Jun 19, 2009·Nature·Susan E CelnikermodENCODE Consortium
Aug 15, 2009·PLoS Genetics·Li JiaGerhard A Coetzee
Aug 18, 2009·Nature Structural & Molecular Biology·Hagen TilgnerRoderic Guigó
Aug 18, 2009·Nature Structural & Molecular Biology·Schraga SchwartzGil Ast
Aug 19, 2009·Genome Research·Robin AnderssonJan Komorowski
Nov 18, 2009·PLoS Computational Biology·Gary HonBing Ren

Citations

Nov 23, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heather J HusonElaine A Ostrander
Jan 19, 2013·Sports Medicine·Tobias EhlertDirk A Moser
Dec 24, 2010·Nature·Peter V KharchenkoPeter J Park
Mar 29, 2011·Nature·Jason ErnstBradley E Bernstein
Oct 14, 2011·Nature·Kerstin Lindblad-TohManolis Kellis
Oct 15, 2010·Nature Biotechnology·Anna Portela, Manel Esteller
Nov 10, 2012·Nature Biotechnology·Lucas D Ward, Manolis Kellis
Oct 15, 2010·Nature Biotechnology·John S SatterleeHuck-Hui Ng
Oct 15, 2010·Nature Biotechnology·Aleksandar Milosavljevic
Aug 21, 2013·Nature Genetics·Daniel ChubbHartmut Goldschmidt
Sep 1, 2011·Nature Methods·Monya Baker
Mar 1, 2012·Nature Methods·Jason Ernst, Manolis Kellis
Mar 20, 2012·Nature Methods·Michael M HoffmanWilliam Stafford Noble
Jul 13, 2011·Nature Reviews. Genetics·Vardhman K RakyanStephan Beck
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hongkai JiYang Ning
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Youssef IdaghdourPhilip Awadalla
Apr 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ruslan I SadreyevJeannie T Lee
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Luca MagnaniMathieu Lupien
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stephen C J ParkerNISC Comparative Sequencing Program Authors
Nov 3, 2012·Briefings in Functional Genomics·Debbie K Goode, Greg Elgar
Dec 17, 2010·Bioinformatics·Melissa S Cline, Rachel Karchin
Apr 2, 2013·Bioinformatics·Xiaoyi Cao, Sheng Zhong
Aug 29, 2013·Bioinformatics·Alessandro MammanaHo-Ryun Chung
Apr 19, 2011·Cardiovascular Research·Mikko P Turunen, Seppo Ylä-Herttuala
Sep 1, 2012·Human Molecular Genetics·Seth J BrownYi Xing
Jun 10, 2011·Nucleic Acids Research·Matthew D YoungIan J Majewski
Sep 21, 2011·Nucleic Acids Research·Jianrong WangI King Jordan
Dec 12, 2012·Nucleic Acids Research·Michael M HoffmanWilliam Stafford Noble
Sep 20, 2012·Nucleic Acids Research·Jianrong WangI King Jordan
Mar 14, 2013·Nucleic Acids Research·Kyoung-Jae WonWei Wang
Apr 16, 2013·Nucleic Acids Research·Yoko ItoAdele Murrell
Jun 15, 2013·Nucleic Acids Research·Nathan Harmston, Boris Lenhard
Jul 6, 2013·Nucleic Acids Research·Lukas BurgerMichael B Stadler
Sep 17, 2013·Nucleic Acids Research·Yun ZhuWei Wang
Sep 17, 2013·Nucleic Acids Research·Marco-Antonio Mendoza-ParraHinrich Gronemeyer
Jan 10, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ghazala BegumAnne White
Sep 8, 2012·Genome Research·Stephen G LandtMichael Snyder
Sep 8, 2012·Genome Research·Alan P BoyleMichael Snyder
Sep 11, 2012·Genome Research·Cydney B NielsenSteven J M Jones
Dec 24, 2010·Science·modENCODE ConsortiumManolis Kellis
Nov 16, 2013·Biochemistry. Biokhimii︠a︡·N A SmirnovE D Sverdlov
May 25, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Abigail L ShearinElaine A Ostrander
Jul 30, 2011·American Journal of Respiratory and Critical Care Medicine·Jamie L ToddScott M Palmer
Nov 16, 2010·BMC Bioinformatics·Jessica L Larson, Guo-Cheng Yuan
Oct 28, 2011·BMC Bioinformatics·Orion J BuskeWilliam Stafford Noble
Dec 7, 2013·BMC Bioinformatics·Mikhail G DozmorovJonathan D Wren
Nov 21, 2012·BMC Genomics·Cenny TaslimTim Hui-Ming Huang
Jan 11, 2013·BMC Genomics·Yupeng HeChaochun Wei
Aug 21, 2013·Retrovirology·Scott Sherrill-MixFrederic D Bushman
Sep 6, 2013·Epigenetics & Chromatin·Marcin CieślikStefan Bekiranov
Nov 28, 2013·Epigenetics & Chromatin·Günter RaddatzFrank Lyko
Oct 2, 2012·Mobile DNA·Andrew B Conley, I King Jordan
Nov 15, 2011·Breast Cancer Research : BCR·Yi HuangSteffi Oesterreich
Dec 25, 2010·Genome Biology·William K M Lai, Michael J Buck
Mar 20, 2012·Genome Biology·Zhen ShaoDavid J Waxman
Jul 13, 2013·Genome Biology·Xin ZengSunduz Keles
Mar 26, 2013·PLoS Computational Biology·Nisha RajagopalBing Ren
Sep 17, 2013·PLoS Computational Biology·Julia LasserreMartin Vingron
Oct 17, 2013·PLoS Computational Biology·Hanna JulienneAlain Arneodo
Jan 28, 2014·PLoS Computational Biology·Federico Comoglio, Renato Paro
Mar 8, 2014·PLoS Computational Biology·Md Abul Hassan Samee, Saurabh Sinha
Mar 29, 2014·PLoS Computational Biology·Jian Zhou, Olga G Troyanskaya
Jun 6, 2014·PLoS Computational Biology·Ondrej PodlahaFranziska Michor
Mar 1, 2012·PloS One·Jessica L Larson, Guo-Cheng Yuan
Apr 13, 2012·PloS One·Ekaterina E KhrameevaMikhail S Gelfand
Jun 23, 2012·Journal of Molecular Endocrinology·Gioia Altobelli
Dec 1, 2011·Epigenomics·Christopher D Green, Jing-Dong J Han
Oct 5, 2013·Haematologica·Joost H A Martens, Hendrik G Stunnenberg
Jun 14, 2012·Epigenomics·Lisa Helbling Chadwick
Dec 19, 2012·Epigenomics·Luca MagnaniMathieu Lupien
Jan 30, 2014·BMC Genomics·Marcin Cieślik, Stefan Bekiranov
Mar 26, 2014·Trends in Genetics : TIG·Xiaoyang ZhangMathieu Lupien
Jul 18, 2014·BMC Systems Biology·Ana Conesa, Ali Mortazavi
Jun 20, 2013·BioMed Research International·Hao Wu, Zhaohui S Qin
Jan 17, 2014·Molecular Biology Reports·Lautaro Zubeldia-BrennerFederico Coluccio Leskow
Nov 2, 2013·Biostatistics·Yanchun BaoPeter A C 't Hoen
Dec 24, 2013·Journal of Molecular Endocrinology·Raffaella Maria Gadaleta, Luca Magnani
May 3, 2014·Blood Cancer Journal·K DimopoulosK Grønbæk
May 30, 2014·Epigenetics & Chromatin·Zhangli SuJohn M Denu
Jan 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Troels T Marstrand, John D Storey
Nov 8, 2013·Briefings in Bioinformatics·Luca PinelloGuo-Cheng Yuan
Jun 12, 2013·ELife·Maria Gutierrez-ArcelusEmmanouil T Dermitzakis
Jan 2, 2014·ELife·Anwesha NagAlexander A Gimelbrant
Apr 17, 2014·Human Molecular Genetics·Nicola WhiffinMalcolm G Dunlop
Aug 19, 2014·Nature Neuroscience·Philip L De JagerDavid A Bennett
Dec 18, 2013·Human Molecular Genetics·Welisane Besingi, Åsa Johansson
Nov 20, 2014·BMC Genomics·Beatrice MilonMaria Nurminskaya
Jul 6, 2014·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Mette BoydAlbin Sandelin
Sep 17, 2014·Nature Reviews. Genetics·Clifford A Meyer, X Shirley Liu
Apr 19, 2012·Nature Chemical Biology·Beat Fierz, Tom W Muir
Mar 7, 2013·Cellular and Molecular Life Sciences : CMLS·Raffaele TeperinoJ Andrew Pospisilik
Jan 26, 2016·Nature Neuroscience·Marit W VermuntMenno P Creyghton
Feb 2, 2016·Journal of Biomedical Informatics·Izaskun MallonaMiguel A Peinado
Sep 24, 2015·Critical Reviews in Clinical Laboratory Sciences·Srilakshmi SrinivasanJyotsna Batra
Aug 1, 2015·Chromosoma·Liron Even-FaitelsonDavid P Bazett-Jones
Jun 4, 2015·Critical Reviews in Biochemistry and Molecular Biology·Shaun Mahony, B Franklin Pugh
Feb 19, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Arundhati BakshiJoomyeong Kim
Dec 3, 2014·Journal of Molecular Biology·Charlène Lemaître, Evi Soutoglou
Oct 5, 2014·Journal of Molecular Biology·Filippo Ciabrelli, Giacomo Cavalli
Sep 10, 2013·Seminars in Nephrology·Yi-An Ko, Katalin Susztak
May 1, 2012·Trends in Genetics : TIG·Marco MagistriClaes Wahlestedt
Apr 3, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wim Vanden Berghe
Feb 3, 2012·Journal of Neuroimmunology·Anna Kaliszewska, Philip L De Jager
Dec 29, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexia Martínez de Paz, Juan Ausió
Nov 12, 2014·Journal of Bioinformatics and Computational Biology·Paweł Bednarz, Bartek Wilczyński
Nov 14, 2015·Molecular Biology of the Cell·Nuno M C MartinsWilliam C Earnshaw
Dec 8, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Edmund C ChangGianpietro Dotti
Jul 19, 2011·Trends in Genetics : TIG·Steven Henikoff, Ali Shilatifard
Jun 15, 2011·Molecular and Cellular Endocrinology·J Wesley Pike
Apr 22, 2011·Trends in Genetics : TIG·Aleksandar Milosavljevic
Apr 19, 2011·Trends in Biochemical Sciences·Matladi N NdlovuFrançois Fuks
Feb 25, 2011·Current Opinion in Genetics & Development·Peter MeisterSusan M Gasser
Nov 18, 2014·Genome Medicine·Niamh M RyanKathryn L Evans
Aug 28, 2012·Comparative and Functional Genomics·Sonja AlthammerEduardo Eyras
Aug 11, 2015·The Plant Journal : for Cell and Molecular Biology·Katie BakerAndrew J Flavell
Oct 6, 2015·Nature Medicine·Leigh GoedekeCarlos Fernández-Hernando
May 20, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tie-Lin YangHongwen Deng
Sep 5, 2015·Pharmacogenomics·Gerald A HigginsBrian D Athey
Oct 13, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ana Antunes-MartinsDavid L H Bennett
Apr 30, 2011·The EMBO Journal·Bas van Steensel
Apr 14, 2011·The EMBO Journal·François RoudierVincent Colot
Oct 26, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T OrdogD T Asuzu
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J Wesley Pike
Feb 22, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Guo-Cheng Yuan
Oct 18, 2012·Wiley Interdisciplinary Reviews. RNA·Luciana I Gómez AcuñaAlberto R Kornblihtt
Dec 6, 2011·Genesis : the Journal of Genetics and Development·Ozren BogdanovićGert Jan C Veenstra
May 16, 2014·Proteomics·Yupeng ZhengSteve M M Sweet
May 2, 2014·The Plant Journal : for Cell and Molecular Biology·Thomas WidiezStefan A Rensing
Dec 7, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Dirk S PaulStephan Beck
Aug 16, 2014·Immunological Reviews·Deborah R Winter, Ido Amit
Mar 24, 2016·Nucleic Acids Research·Georges St LaurentPhilipp Kapranov
Jul 17, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jingchen Chen, Andrea Streit
May 13, 2014·Experimental Hematology·Koen H M PrangeJoost H A Martens
Dec 14, 2011·Cell Metabolism·Rana K GuptaBruce M Spiegelman
Apr 11, 2013·Genomics·Jessica L LarsonGuo-Cheng Yuan
Oct 3, 2015·American Journal of Human Genetics·Halit Ongen, Emmanouil T Dermitzakis
Oct 2, 2015·BioMed Research International·Yuming ZhaoLiran Juan
Aug 17, 2015·Trends in Immunology·Steven WitteGolnaz Vahedi
Sep 1, 2015·Nucleic Acids Research·Mylène BrunelleNicolas Gévry
Sep 1, 2015·BMC Genomics·Rongxin FangZhihua Zhang
Aug 4, 2012·Current Opinion in Immunology·Amy LeungRama Natarajan
Nov 19, 2013·The Journal of Steroid Biochemistry and Molecular Biology·J Wesley Pike, Mark B Meyer
Mar 20, 2015·Bioinformatics·Li TengKai Tan
Mar 27, 2015·Bioinformatics·Michiaki HamadaKiyoshi Asai
Jul 4, 2015·BioData Mining·Pedro Madrigal, Paweł Krajewski
Mar 1, 2015·Bioinformatics·Kyung-Ah SohnJu Han Kim
Mar 19, 2015·Genome Biology·Jimin Song, Kevin C Chen
Mar 20, 2013·Seminars in Hematology·Kristen H TaylorCharles W Caldwell
Jun 1, 2011·Biomolecular Concepts·Tiia HussoSeppo Ylä-Herttuala
Oct 14, 2014·American Journal of Human Genetics·E R GamazonLea K Davis
Dec 13, 2012·Nucleus·Tamir Chandra, Masashi Narita
May 21, 2013·Molecular and Cellular Endocrinology·Luca Magnani, Mathieu Lupien
Mar 24, 2015·Nature Methods·Charles G DankoAdam Siepel
Aug 26, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Andrey PoleshkoRichard A Katz
Nov 12, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Mikhail G DozmorovMarta E Alarcón-Riquelme
Jan 1, 2013·Current Opinion in Genetics & Development·Carolyn A de Graaf, Bas van Steensel
Dec 26, 2012·Current Opinion in Genetics & Development·Michael J Guertin, John T Lis
Feb 6, 2015·Human Molecular Genetics·Nick OrrAustralian Ovarian Cancer Study Group
Jun 9, 2012·Mutation Research·Eileen PernotElisabeth Cardis
Apr 11, 2015·Clinical Epigenetics·Katarzyna Szarc Vel SzicWim Vanden Berghe
Mar 19, 2013·Cell·Wendy A Bickmore, Bas van Steensel
Jun 12, 2012·Cell·Shu XiaoSheng Zhong
Dec 4, 2012·Molecular Cell·Joshua C BlackJohnathan R Whetstine
Feb 27, 2013·Molecular Cell·Alex M Plocik, Brenton R Graveley
Feb 27, 2013·Molecular Cell·Joke G van BemmelBas van Steensel
Jun 20, 2012·Journal of Theoretical Biology·Inkyung Jung, Dongsup Kim
Jul 25, 2013·Journal of Theoretical Biology·Christian ArnoldSonja J Prohaska
Nov 26, 2013·American Journal of Human Genetics·Konstantin PopadinStylianos E Antonarakis
Feb 5, 2015·Nature Reviews. Molecular Cell Biology·Sven HeinzChristopher K Glass
Oct 9, 2014·Frontiers in Genetics·Stefano de Pretis, Mattia Pelizzola
Sep 2, 2014·Frontiers in Genetics·Elena Gómez-DíazVictor G Corces
Nov 8, 2014·Nucleic Acids Research·Dimitrios KleftogiannisVladimir B Bajic
Apr 27, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S-S DongT-L Yang
Dec 4, 2014·Trends in Genetics : TIG·Dan Chen, Ulf Gyllensten
Dec 1, 2015·PloS One·Giorgio Bernardi
May 10, 2016·Nature Reviews. Genetics·Aaron TaudtFrank Johannes
May 18, 2016·Progress in Lipid Research·Marthe-Susanna WegnerSabine Grösch
Jul 24, 2013·Genome Biology·Georges St LaurentPhilipp Kapranov
Jun 4, 2016·Nucleic Acids Research·Jeffrey M Bhasin, Angela H Ting
Sep 4, 2015·Chromosoma·Joana Sequeira-Mendes, Crisanto Gutierrez
Jan 9, 2015·PLoS Genetics·Athma A PaiYoav Gilad
Jan 31, 2015·PLoS Genetics·Maria Gutierrez-ArcelusEmmanouil T Dermitzakis
Jul 10, 2016·Journal of Translational Medicine·Estela G TorañoAgustin F Fernández
Jul 12, 2016·Nature·Christian FuchsbergerMark I McCarthy
Jul 15, 2016·International Journal of Hematology·Yusuke Furukawa, Jiro Kikuchi
Jul 20, 2016·Nature Neuroscience·Alexi NottLi-Huei Tsai
Jul 6, 2016·Bioinformatics·Hamid YounesyTorsten Möller
Jul 2, 2015·Annual Review of Genomics and Human Genetics·James B Brown, Susan E Celniker
Aug 23, 2016·Future Medicinal Chemistry·David S RogawskiTomasz Cierpicki
May 6, 2016·Annual Review of Genomics and Human Genetics·Steven K Reilly, James P Noonan
Sep 17, 2016·BMC Medical Genomics·Subhojit SenHariharan Easwaran
Sep 24, 2016·Journal of Biomolecular Structure & Dynamics·Sanga MitraJayprokas Chakrabarti
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kenneth J EvansJulie Ahringer
Nov 12, 2016·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Chandler ZuoSunduz Keles
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sharon R GrossmanEric S Lander
Jan 26, 2017·Human Mutation·Michael A Beer
Jan 24, 2016·Cold Spring Harbor Symposia on Quantitative Biology·Giorgio Bernardi
Jul 15, 2015·Scientific Reports·Sachin Pundhir, Jan Gorodkin
Jul 15, 2015·Scientific Reports·Hongying ZhaoXia Li
May 23, 2017·Nature Reviews. Genetics·Olivier Cuvier, Beat Fierz
May 23, 2017·Nature Genetics·Joanna M M HowsonDanish Saleheen
Apr 16, 2017·Experimental Hematology·Andrea A PerreaultBryan J Venters
Jun 6, 2017·Genomics·Nighat NoureenSahar Fazal
Apr 15, 2014·Nature Methods·Theo A KnijnenburgIlya Shmulevich
Mar 15, 2014·Epidemiology·Farren B S BriggsLisa F Barcellos
Jan 25, 2017·Epigenetics & Chromatin·Pavla NavratilovaEric M Thompson
Apr 8, 2017·Nature Communications·Eugenio MarcoGuo-Cheng Yuan
Apr 6, 2017·BMC Genomics·Wenze HuangChaochun Wei
Jun 5, 2014·Inflammatory Bowel Diseases·Jan Däbritz, Trevelyan R Menheniott
Sep 22, 2017·Nucleic Acids Research·Enrique Carrillo-de-Santa-PauBLUEPRINT Consortium
Oct 19, 2017·Nucleic Acids Research·Yue LiuZhen Su
Feb 28, 2018·Frontiers in Immunology·Miriam G Jasiulionis
Jun 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jinchuan HuAziz Sancar
Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Nassim E AjamiShankar Subramaniam
Oct 24, 2013·Nature Communications·Matthew FramptonRichard S Houlston
Oct 1, 2014·Nature Communications·Lijing YaoPeggy J Farnham
Dec 8, 2015·Evolutionary Bioinformatics Online·Paolo CozziGiorgio Bernardi
Oct 24, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Francesco N CarelliJulie Ahringer
Dec 17, 2016·Bioinformatics and Biology Insights·Yixing Han, Ximiao He
Dec 24, 2017·Nature Communications·Owen J Marshall, Andrea H Brand
Jun 8, 2018·Human Molecular Genetics·Agustin F FernándezMario F Fraga
Jun 25, 2014·Proteomics. Clinical Applications·Emma Monte, Thomas M Vondriska
Jun 1, 2018·Annual Review of Genomics and Human Genetics·Liad Holtzman, Charles A Gersbach
Aug 23, 2017·PLoS Computational Biology·Remo MontiLen A Pennacchio
Oct 27, 2018·ELife·Jürgen JänesJulie Ahringer
Mar 11, 2016·Nature Communications·Yun ZhuWei Wang
Sep 28, 2018·Experimental Dermatology·María C Ovejero-BenitoFrancisco Abad-Santos
Oct 26, 2018·Genome Research·Yoon Jung KimTae Hoon Kim
Dec 12, 2018·Bioinformatics·Sarah N MapelliCarlo V Catapano
Oct 3, 2017·Briefings in Bioinformatics·Shan-Shan DongTie-Lin Yang
Jan 25, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Sarah W CurtisAlicia K Smith
Mar 6, 2019·Scientific Data·Andrea A PerreaultBryan J Venters
Dec 1, 2010·Nature Reviews. Genetics·Vicky W ZhouBradley E Bernstein
May 3, 2019·Scientific Reports·Sang Hoon LeeLudvig Lizana
Mar 7, 2012·Nature Reviews. Genetics·Boris LenhardPiero Carninci
Sep 8, 2012·Nature·Sarah DjebaliThomas R Gingeras
Jun 11, 2019·PLoS Computational Biology·Yifeng Qi, Bin Zhang
Mar 14, 2012·EMBO Reports·Timothée Lionnet, Robert H Singer
May 1, 2019·EMBO Reports·Janet C HarwoodAdrian J Harwood
Jul 10, 2019·Communications Biology·Adriana Arneson, Jason Ernst
Feb 21, 2018·BMC Developmental Biology·Anna MantsokiAnagha Joshi
Nov 5, 2019·PLoS Computational Biology·Yu Zhang, Shaun Mahony
Jun 14, 2013·BMC Bioinformatics·Jacob BiesingerXiaohui Xie
Oct 18, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Andrea L Wurster, Michael J Pazin
Apr 15, 2020·RNA Biology·Hagen SchwenzerSarah P Blagden
Sep 4, 2015·Genome Biology·Ferhat Ay, William Stafford Noble
May 16, 2020·International Journal of Molecular Sciences·Iván Fernández-FríasJavier Díaz-Nido
Feb 21, 2020·Neurogenetics·Tanya Ramdal TechloThomas Folkmann Hansen
May 29, 2020·Nature Communications·Lun ZhaoXingwang Li
Jul 15, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Sarah W CurtisAlicia K Smith
Sep 15, 2020·The FEBS Journal·Ben Vanderkruk, Brad G Hoffman
Jan 12, 2011·Nature Biotechnology·H Craig Mak
Feb 20, 2015·Nature·Roadmap Epigenomics ConsortiumManolis Kellis
Mar 1, 2013·Quantitative Biology·Hyunjin ShinX Shirley Liu
Nov 6, 2015·Clinical Epigenetics·Tanja BožićWolfgang Wagner
Nov 20, 2016·Cold Spring Harbor Perspectives in Medicine·Daniel N WeinbergChao Lu
Jul 9, 2017·Chromosoma·Oscar MolinaWilliam C Earnshaw
May 23, 2017·Cell & Bioscience·Daniel NorthrupKeji Zhao
May 8, 2018·Nucleic Acids Research·Meng NiuZhengchang Su
Sep 25, 2018·Nucleic Acids Research·Jing WangYu Shyr
Aug 26, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Paul J SmithRachel J Errington
Feb 14, 2019·Diabetologia·Yasuhiro KyonoStephen C J Parker
Nov 17, 2016·Genome Biology·Kai WeiWilliam Stafford Noble
May 19, 2017·Epigenetics & Chromatin·Francesco Gandolfi, Anna Tramontano
Aug 15, 2018·Nucleic Acids Research·Thuy-Ai T NguyenDaniel Menendez
Apr 26, 2019·Archives of Pharmacal Research·Ja-Eun Kim
Nov 20, 2019·Nature Methods·Rachael E WorkmanWinston Timp
Sep 4, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Madeleine FosslieJohn Arne Dahl
Feb 29, 2020·Nature Communications·Matteo SesiaChiara Sabatti
Dec 14, 2019·PLoS Genetics·Jennifer ZouEleazar Eskin
Mar 27, 2020·Frontiers in Genetics·Kellen G Cresswell, Mikhail G Dozmorov
Dec 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander V PredeusMaxim N Artyomov
Feb 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Arushi VarshneyMichael L Stitzel
May 26, 2017·Genome Biology·Zaida Vergara, Crisanto Gutierrez
Aug 1, 2017·Breast Cancer Research and Treatment·Allyson C EspinalMichael J Higgins
Nov 10, 2017·Nature Protocols·Jason Ernst, Manolis Kellis
Aug 16, 2017·Nature Communications·Anniina VihervaaraLea Sistonen
Mar 30, 2017·Bioscience Reports·Zhenhua Hu, Wee-Wei Tee
Jun 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Zhana DurenWing Hung Wong
Dec 16, 2017·Genetics·Liangjun WangJeffrey A Simon
May 5, 2018·Molecular Omics·Minseung Kim, Ilias Tagkopoulos
May 4, 2018·Proceedings. Biological Sciences·Theresa K KellySarah E London
Sep 26, 2018·Nature Communications·Malay MandalMarcus R Clark
Dec 18, 2019·The Journal of Clinical Investigation·Christopher L NoblesFrederic D Bushman
Aug 11, 2019·Nature Reviews. Genetics·Erin M WissinkJohn T Lis
Nov 10, 2015·Nature Genetics·Kyle J GaultonDIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
Feb 6, 2018·PLoS Computational Biology·Pau Farré, Eldon Emberly
Sep 29, 2017·Scientific Reports·Rainer MachnéPeter F Stadler
Mar 27, 2018·Briefings in Functional Genomics·Shan Jiang, Ali Mortazavi
Nov 21, 2018·Life Science Alliance·Noriko HosoyaKiyoshi Miyagawa
Apr 13, 2018·Nucleic Acids Research·Wendy N JeffersonCarmen J Williams
Apr 24, 2018·Clinical Epigenetics·Sabine A S LangiePatrick De Boever
Mar 25, 2019·Biochemical Society Transactions·Caroline Delandre, Owen J Marshall
Oct 4, 2020·Epigenetics & Chromatin·Benjamin E DecatoAndrew D Smith
Oct 8, 2020·Scientific Reports·Vasilis F NtasisChristoforos Nikolaou
Oct 21, 2020·BMC Bioinformatics·Arnaud CeolMarco Masseroli
Nov 6, 2020·Transcription·Nahyun Kong, Inkyung Jung
Dec 29, 2020·Frontiers in Genetics·Yan Zhang, Dianjing Guo
Nov 29, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Laura P SpectorMark A Kay
Feb 6, 2020·Computational and Structural Biotechnology Journal·Stylianos Mavropoulos PapoudasChristoforos Nikolaou
Jul 3, 2020·Computational and Structural Biotechnology Journal·Barbara HöllbacherN Henriette Uhlenhaut
Sep 1, 2017·Genetics·Chloe RobinsKaren N Conneely
Sep 7, 2017·Marija StrojnikGuillermo Garcia-Torales

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COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.