Discovery and Development of Gaseous Nitric Oxide Under Increased Atmospheric Pressure as an Antimicrobial: In Vitro and In Vivo Testing of Nitric Oxide Against Multidrug-Resistant Organisms

Clinics in Podiatric Medicine and Surgery
Jeffrey JensenSteven Jensen

Abstract

Gaseous nitric oxide under increased atmospheric pressure (gNOp) has shown ability to kill multidrug-resistant bacteria in an in vitro model and in a live mammalian (porcine) model. Factors impacting the kill rate of the multidrug-resistant bacteria include atmospheric pressures, concentration of gaseous NO, flow rate, and duration of application. Using successful in vitro parameters, gNOp showed multilog reduction of bacteria in a live mammalian (porcine) model. The in vitro testing system, using the EpiDerm-FT skin model (stem cell grown skin), was used to develop an infected wound model for Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, and methicillin-resistant S aureus.

References

May 1, 1990·Diabetes Care·R E PecoraroE M Burgess
Nov 26, 2002·The British Journal of Surgery·M B WitteA Barbul
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Nalini SinghBenjamin A Lipsky
Mar 31, 2005·Nitric Oxide : Biology and Chemistry·A GhaffariC C Miller
May 30, 2006·Diabetes Care·Lawrence A LaveryBenjamin A Lipsky
Oct 20, 2006·Journal of Bacteriology·Nicolas BarraudJeremy S Webb
Jun 1, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Abdi GhaffariAziz Ghahary
Sep 16, 2008·Nitric Oxide : Biology and Chemistry·Chris MillerYossef Av-Gay
Aug 4, 2010·Applied Microbiology and Biotechnology·Mitchell Lawrence JonesSatya Prakash
Feb 22, 2012·Nitric Oxide : Biology and Chemistry·Benjamin J PrivettMark H Schoenfisch
Oct 17, 2013·Diabetic Foot & Ankle·Neal R BarshesDavid G Armstrong
Nov 5, 2013·Diabetes Care·J Bradford RiceNathan B Parsons
Jan 7, 2018·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Samuel R NussbaumDonna Cartwright
Jan 19, 2018·Therapeutic Advances in Endocrinology and Metabolism·Alok RaghavBrijesh Kumar Mishra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.

Related Papers

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
O GustavssonA Bredberg
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Anucha Apisarnthanarak, Linda M Mundy
Emerging Infectious Diseases
Vladimir Krcmery, Erich Kalavsky
© 2021 Meta ULC. All rights reserved