Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV)

Advances in Experimental Medicine and Biology
Wendy A Knowles

Abstract

Although discovered over thirty years ago, many aspects of the epidemiology of BKV and JCV in the general population, such as the source of infectious virus and the mode of transmission, are still unknown. Primary infection with both BKV and JCV is usually asymptomatic, and so age seroprevalence studies have been used to indicate infection. BKV commonly infects young children in all parts of the world, with the exception of a few very isolated communities, adult seroprevalence rates of 65-90% being reached by the age of ten years. In contrast, the pattern of JCV infection appears to vary between populations; in some anti-JCV antibody is acquired early as for BKV, but in others anti-JCV antibody prevalence continues to rise throughout life. This indicates that the two viruses are probably transmitted independently and by different routes. Whilst BKV DNA is found infrequently in the urine of healthy adults, JCV viruria occurs universally, increasing with age, with adult prevalence rates often between 20% and 60%. Four antigenic subtypes have been described for BKV and eight genotypes are currently recognized for JCV. The latter have been used to trace population movements and to reconstruct the population history in various commu...Continue Reading

Citations

Mar 12, 2013·Nature Reviews. Microbiology·James A DeCaprio, Robert L Garcea
Jun 16, 2011·The Journal of Infectious Diseases·Carl E ReidJohn P Carulli
Sep 25, 2009·Journal of the National Cancer Institute·Joseph J CarterDenise A Galloway
Mar 5, 2009·Antimicrobial Agents and Chemotherapy·Margot BrickelmaierLeonid Gorelik
Jun 6, 2009·Journal of Clinical Microbiology·John A VanchiereJanet S Butel
Feb 9, 2007·Journal of Virology·Tobias AllanderBjörn Andersson
Jun 29, 2012·Journal of Virology·Erica A SiebrasseDavid Wang
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael SelgradC Richard Boland
Aug 30, 2013·Virology Journal·Ole LagatieLieven J Stuyver
Jul 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Rockville Merkel Cell Carcinoma Group
Aug 23, 2012·PloS One·Manola ComarMauro Tognon
Mar 28, 2009·PLoS Pathogens·Jaime M KeanRobert L Garcea
Aug 2, 2011·Emerging Infectious Diseases·Yanis L TolstovYuan Chang
Apr 23, 2013·Clinical & Developmental Immunology·Michela CioniHans H Hirsch
Jun 16, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Daniel L KeeneDuc Vu
May 21, 2016·Journal of the Pediatric Infectious Diseases Society·John A VanchiereJanet S Butel
Mar 18, 2016·Clinical Kidney Journal·Sarat KuppachiChristie P Thomas
Dec 23, 2015·Emerging Infectious Diseases·Erica A SiebrasseDavid Wang
Sep 24, 2011·Pathology Research International·Ugo MoensMarijke Van Ghelue
Feb 21, 2013·Clinical & Developmental Immunology·Serena DelbuePasquale Ferrante
May 19, 2012·Immunopharmacology and Immunotoxicology·Guglielmo Lucchese
Dec 23, 2014·Emerging Infectious Diseases·Erica A SiebrasseDavid Wang
Jun 9, 2016·Human Genetics·Daniel StoneKeith R Jerome
Jul 8, 2016·Journal of Medicinal Chemistry·Dominique BonafouxErnst Ter Haar
Feb 7, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Frédéric BacchettaRenaud Du Pasquier
Mar 12, 2016·Journal of Infection and Public Health·Samah A LoutfyEl-Chaimaa B Mohamed
Jun 25, 2014·Virus Research·Bethany A O'HaraWalter J Atwood
May 26, 2017·Current Opinion in Organ Transplantation·Stephanie G YiKeri E Lunsford
Nov 26, 2015·Therapeutic Advances in Neurological Disorders·Dejan PavlovicUNKNOWN Progressive Multifocal Leukeoncephalopathy Consortium
Dec 1, 2009·Viruses·Michael KleinesSimone Scheithauer
Jul 15, 2015·The Journal of Pathology·Daniel J KenanVolker Nickeleit
Sep 16, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eric M L Williamson, Joseph R Berger
Apr 13, 2018·The Journal of Clinical Investigation·Gina A Montealegre SanchezRaphaela Goldbach-Mansky

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