Discovery and Functional Annotation of Quantitative Trait Loci Affecting Resistance to Sea Lice in Atlantic Salmon

Frontiers in Genetics
Diego RobledoJosé M Yáñez

Abstract

Sea lice (Caligus rogercresseyi) are ectoparasitic copepods which have a large negative economic and welfare impact in Atlantic salmon (Salmo salar) aquaculture, particularly in Chile. A multi-faceted prevention and control strategy is required to tackle lice, and selective breeding contributes via cumulative improvement of host resistance to the parasite. While host resistance has been shown to be heritable, little is yet known about the individual loci that contribute to this resistance, the potential underlying genes, and their mechanisms of action. In this study we took a multifaceted approach to identify and characterize quantitative trait loci (QTL) affecting host resistance in a population of 2,688 Caligus-challenged Atlantic salmon post-smolts from a commercial breeding program. We used low and medium density genotyping with imputation to collect genome-wide SNP marker data for all animals. Moderate heritability estimates of 0.28 and 0.24 were obtained for lice density (as a measure of host resistance) and growth during infestation, respectively. Three QTL explaining between 7 and 13% of the genetic variation in resistance to sea lice (as represented by the traits of lice density) were detected on chromosomes 3, 18, and...Continue Reading

References

Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Oct 10, 2007·American Journal of Human Genetics·Wei-Min Chen, Goncalo Abecasis
Feb 28, 2009·Journal of Fish Diseases·Mark J Costello
Jun 10, 2009·Bioinformatics·Heng Li1000 Genome Project Data Processing Subgroup
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martina GatzkaCraig M Walsh
Sep 17, 2011·Nature·Thomas M KeaneDavid J Adams
Oct 6, 2012·Journal of Animal Science·Hans D DaetwylerB J Hayes
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Jun 1, 1968·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W G Hill, A Robertson
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Jun 18, 2014·BMC Genomics·Mehdi SargolzaeiFlavio S Schenkel
Jul 30, 2014·Clinical & Experimental Neuroimmunology·Sergio E Baranzini
Dec 3, 2014·Developmental and Comparative Immunology·Laura M BradenSimon R M Jones
Dec 9, 2014·Frontiers in Genetics·Jørgen OdegårdTheo H E Meuwissen
Dec 19, 2014·BMC Proceedings·Valentina Riggio, Ricardo Pong-Wong
Feb 3, 2015·Trends in Parasitology·Stian Mørch AaenTor Einar Horsberg
Feb 25, 2015·Nature Reviews. Genetics·Frank W Albert, Leonid Kruglyak
Aug 21, 2015·Journal of the Royal Society, Interface·Karim GharbiMichael J Stear
Dec 15, 2015·Nature Communications·Oriol Canela-XandriAlbert Tenesa
Apr 19, 2016·Nature·Sigbjørn LienWilliam S Davidson
Jul 1, 2016·Genetics, Selection, Evolution : GSE·Hsin-Yuan TsaiRoss D Houston
Oct 13, 2017·Nature·GTEx ConsortiumStephen B Montgomery
Feb 9, 2018·G3 : Genes - Genomes - Genetics·Diego RobledoRoss D Houston

Citations

Methods Mentioned

BETA
genotyping
genoyping
PCR
Dissect
RNA-Seq

Related Concepts

Biological Markers
Breeding
Chromosomes
Genes
Genome
Lice
Parasites
Body Louse Infestation
Selection, Genetic
Transcription Factor

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