Discovery and informing research participants of incidental findings detected in brain magnetic resonance imaging studies: Review and multi-institutional study

Brain and Behavior
Kyoko TakashimaAkira Akabayashi

Abstract

Brain imaging studies using magnetic resonance imaging (MRI) sometimes reveal incidental findings (IFs) that might be relevant to some of the health issues in research participants. Although professional communities have discussed how to manage these IFs, there is no global consensus on the concrete handling procedures including how to inform participants of IFs. First, this study reviewed previous studies for the number of IFs discovered in brain imaging studies using MEDLINE. Second, a multi-institutional study determined the number of IF discoveries and evaluated the method of informing participants at multiple institutions, which participated in a national brain science project in Japan. Both the review and multi-institutional study showed that IFs with a high urgency level were discovered in 0-2.0% of participants, including healthy volunteers, and that the rate of IF discovery in general was higher in studies conducted in elderly population. Moreover, multi-institutional study suggested the criteria used to judge whether or not to inform participants of IFs may differ by institution. Our results suggest that in order to ensure informing the participants of high urgency IFs, physicians who are capable of interpreting brain...Continue Reading

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Citations

Jun 13, 2020·Scientific Reports·Kevin F HannaSusan Swindells
Mar 24, 2021·Aerospace Medicine and Human Performance·Sven-Erik SönksenFrank Weber
Jul 22, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Vladimir IvanovicMichael L Lipton

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