Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis

Journal of Medicinal Chemistry
Jason G KettleDavid Whittaker

Abstract

Potent and selective inhibitors of Dyrk1B kinase were developed to explore the hypothesis, based on siRNA studies, that Dyrk1B may be a resistance mechanism in cells undergoing a stress response.

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Citations

Apr 15, 2017·Bioorganic & Medicinal Chemistry Letters·Simon J ShawTodd M Kinsella
Jan 24, 2019·Journal of Molecular Modeling·Agnieszka Szamborska-GburMarcin Król
Dec 30, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gabriella CastoriaAntimo Migliaccio
Jan 29, 2021·World Journal of Stem Cells·Nikolaos Kokkorakis, Maria Gaitanou
Jun 29, 2021·Bioorganic & Medicinal Chemistry Letters·Areum ParkHyuk Lee
Jan 8, 2020·Journal of Chemical Information and Modeling·Lucia FusaniIan D Wall

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